Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss
de Moraes Campos TA, Brasil RLF, Bezerra FF
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Gobierno
- FundaÇÃo Carlos Chagas Filho de Amparo À Pesquisa do Estado do Rio de Janeiro
- Gobierno
- CoordenaÇÃo de AperfeiÇoamento de Pessoal de NÍvel Superior
- Subvenciones
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/204.084/2024); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/211.841/2021); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/211.229/2021)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-01 · J Hum Nutr Diet · vol. 39 · número 3 · pág. e70293
- Editorial
- Wiley
- Citado
- 0 citas · más que el 43% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Regulation of Appetite and Obesity · Bariatric Surgery and Outcomes
- Palabras clave
- time-restricted eating, morbid obesity, weight loss, caloric restriction, adaptive thermogenesis, resting metabolic rate, leptin, insulin, thyroid-stimulating hormone, appetite, hunger, body composition
- MeSH
- humans, obesity, morbid, weight loss, leptin, absorptiometry, photon, basal metabolism, caloric restriction, diet, reducing, calorimetry, indirect, appetite, adaptation, physiological, body composition, energy metabolism, energy intake, thermogenesis, adult, middle aged, female, male, young adult, intermittent fasting
3 autores
- Tatiana Almeida de Moraes Campos🇧🇷 · autor de correspondenciaUniversidade do Estado do Rio de Janeiro
- Raiane Lira Freitas Brasil🇧🇷Universidade do Estado do Rio de Janeiro
- Flávia Fioruci Bezerra🇧🇷Universidade do Estado do Rio de Janeiro
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To compare metabolic adaptations at the early phase of weight loss in individuals with severe obesity assigned to two strategies of energy restriction: continuous or in combination with time-restricted eating (TRE).
Methods
100 participants (> 40 kg/m2; 20-60 years) were randomized into two groups: continuous energy restriction (CER, n = 42) and TRE combined with energy restriction (TRE + ER; eating window: 10am-6pm). Resting metabolic rate (RMR) by indirect calorimetry, body composition by dual-energy X-ray absorptiometry (DXA), serum hormones, and appetite feelings were evaluated at baseline and after 1 week of prescribed diet at 60% the total energy expenditure. Early adaptive thermogenesis (AT) was calculated using measured and predicted RMR. Data were evaluated using ANCOVA and linear mixed-effects model.
Results
After adjustment for RMR at baseline and body composition, RMR after 1 week was similar between groups (β_group = 47 ± 32 kcal/day; p = 0.148). Early AT was significantly lower in the TRE + ER group (-13 ± 160 kcal vs. -83 ± 150 kcal; p = 0.038). After a week of energy restriction, leptin, insulin, and TSH concentrations decreased in both groups (time effect, p < 0.05) with no group x time interaction. The feeling of hunger increased after 1 week only in the CER group (p = 0.048).
Conclusion
Results suggest that TRE modestly attenuate early AT, but this effect does not translate into differences in RMR after 1 week. Hormonal and appetite responses were also not substantially affected by TRE. Further studies are needed to determine whether the modest early effects of TRE translate into clinically meaningful long-term benefits for weight management.
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