Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study
Lara Moreno J, Li L, Alonso A, Romaguera D, Alonso-Gómez AM, Razquin C, Tojal-Sierra L, Fiol M, Martinez-Gonzalez MA, Subramanya V, Salas-Salvadó J, Fitó M, Toledo E
Nutrients · 0 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Generalitat Valenciana
- Gobierno
- Instituto de Salud Carlos III
- Gobierno
- European Regional Development Fund
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- European Research Council
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- European Regional Development Fund (PI14/00636); European Regional Development Fund (PI19/00957); European Regional Development Fund (PI14/00853); European Regional Development Fund (PI19/00017); European Regional Development Fund (PI14/00972); European Regional Development Fund (PI17/01732); European Regional Development Fund (PI14-00696); European Regional Development Fund (PI16/00662); European Regional Development Fund (PI16/01522); European Regional Development Fund (PI17/00855); European Regional Development Fund (PI16/00381); European Regional Development Fund (PI14/01374); European Regional Development Fund (PI13/00728); European Regional Development Fund (PI13/01090); European Regional Development Fund (PI14/01919); European Regional Development Fund (PI17/00525); European Regional Development Fund (PI17/01183); European Regional Development Fund (PI14/00618); European Regional Development Fund (PI19/00576); European Regional Development Fund (PI14/01206); European Regional Development Fund (PI17/01441); European Regional Development Fund (PI13/00233); European Regional Development Fund (PI19/01332); European Regional Development Fund (PI17/00215); European Regional Development Fund (CB06/03); European Regional Development Fund (PI13/02184); European Regional Development Fund (PI16/00473); European Regional Development Fund (PI13/01123); European Regional Development Fund (PI13/00272); European Regional Development Fund (PI17/00532); European Regional Development Fund (PI19/00781); European Regional Development Fund (PI19/01226); European Regional Development Fund (PI16/01094); European Regional Development Fund (PI16/00501); European Regional Development Fund (P I13/00673); European Regional Development Fund (PI17/00926); European Regional Development Fund (PI13/00492); European Regional Development Fund (PI14/0147); European Regional Development Fund (PI19/00309); European Regional Development Fund (PI19/00386); European Regional Development Fund (PI17/01347); European Regional Development Fund (PI16/00533); National Heart, Lung, and Blood Institute (R01HL137338); European Regional Development Fund (PI17/00764); European Regional Development Fund (PI17/01827); European Regional Development Fund (PI16/01873); European Regional Development Fund (PI16/00366); European Regional Development Fund (PI16/01120); European Regional Development Fund (PI13/00462); European Regional Development Fund (PI19/01032); European Regional Development Fund (PI19/01560); European Regional Development Fund (PI13/01056); European Regional Development Fund (PI17/00508); European Regional Development Fund (PI14/01722)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-05-23 · Nutrients · vol. 18 · número 11 · pág. 1669
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 33% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Atrial Fibrillation Management and Outcomes
- Palabras clave
- omega-3 fatty acids, dietary intake, atrial fibrillation, circulating biomarkers, NT-proBNP, high-sensitivity troponin T, C-reactive protein, procollagen type I C-terminal propeptide, nitrotyrosine, oxidative stress, metabolic syndrome, PREDIMED-Plus trial
- MeSH
- humans, atrial fibrillation, fatty acids, omega-3, peptide fragments, c-reactive protein, longitudinal studies, cross-sectional studies, aged, middle aged, spain, female, male, biomarkers
13 autores
- Jaime Lara Moreno🇪🇸Universidad de Navarra
- Linzi Li🇺🇸Emory University
- Álvaro Alonso🇺🇸Emory University
- Dora Romaguera🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Health Research Institute of the Balearic Islands
- Ángel M. Alonso‐Gómez🇪🇸University of the Basque Country; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
- Cristina Razquín🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- Lucas Tojal‐Sierra🇪🇸University of the Basque Country; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
- Miquel Fiol🇪🇸Health Research Institute of the Balearic Islands
- Miguel Ángel Martínez‐González🇺🇸🇪🇸Harvard University; Navarre Institute of Health Research; Universidad de Navarra
- Vinita Subramanya🇺🇸Emory University
- Jordi Salas‐Salvadó🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat Rovira i Virgili
- Fitó Montserrat🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Del Mar; Municipal Institute for Medical Research; Hospital del Mar Research Institute
- Estefanía Toledo🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Whether habitual dietary omega-3 fatty acid intake is reflected in circulating biomarkers of atrial fibrillation (AF)-related pathways is unclear. We assessed whether usual dietary intake of n-3 fatty acids-considered as total, marine-derived, or non-marine-derived-was associated with the trajectories of five serum markers that reflect AF-related mechanistic pathways [N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (CRP), the C-terminal propeptide of type-I procollagen (PICP), and 3-nitrotyrosine (3-NT)] over 5 years of follow-up. Methods: In 510 participants of the PREDIMED-Plus trial (older Spanish adults with metabolic syndrome), we measured plasma NT-pro-BNP, hs-TnT, CRP, PICP, and 3-NT at baseline and after 3 and 5 years. Energy-adjusted omega-3 intake was assessed with a validated 143-item food-frequency questionnaire. Cross-sectional and 5-year longitudinal associations according to tertiles of omega-3 fatty acid intake were estimated with linear regression and mixed-effects models. Results: Median total omega-3 intake was 2.0 g/day. Total omega-3 intake was not associated with any biomarker, neither cross-sectionally nor longitudinally. Marine omega-3 was directly associated cross-sectionally with 3-NT (highest vs. lowest tertile +28.4%, 95% CI 5.5 to 56.2; p-trend = 0.014) but not longitudinally. Moderate baseline non-marine omega-3 fatty acid intake was associated with a decrease in PICP after 5 years of follow-up. Conclusions: Overall, habitual total omega-3 fatty acid intake was not associated with circulating AF-related pathways. The sporadic association between marine omega-3 fatty acid intake and 3-NT in the cross-sectional assessment and the isolated non-linear association between baseline non-marine omega-3 fatty acid intake and PICP after 5 years warrant further investigation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.