Financiado en parte por Danone, Instituto Danone
Age-Specific Analysis of the Effects of Intermittent Fasting on Body Composition and Cardiometabolic Markers in Healthy Adults and Individuals with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Xing K, Liu R, Peng S, Zi X, Lian L, Yang B, Cen Y, Li Y, Zhao Y, Zhang Y
Nutrients · 0 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Ningxia Medical University
- Gobierno
- Natural Science Foundation of Ningxia Province
- Empresa
- Instituto Danone
- Subvenciones
- National Natural Science Foundation of China (U22A20360); Ningxia Medical University (XJKF240319); National Natural Science Foundation of China (82460656)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-03 · Nutrients · vol. 18 · número 11 · pág. 1799
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 1 cita · más que el 85% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 90 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, age-specific effects, body composition, cardiometabolic biomarkers, weight management, fat-free mass loss, fat mass, insulin sensitivity, HOMA-IR, fasting insulin, LDL cholesterol, triglycerides, blood pressure, time-restricted feeding, intermittent energy restriction, obesity, overweight, older adults, middle-aged adults, young adults, protein intake, resistance training, lipid monitoring
- MeSH
- humans, obesity, age factors, body composition, blood pressure, adult, middle aged, female, male, overweight, randomized controlled trials as topic, biomarkers, intermittent fasting
10 autores
- Kaijun Xing🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Ruihan Liu🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Shenglin Peng🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Xuanxuan Zi🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Linxi Lian🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Bowen Yang🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Yangyang Cen🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Yichao Li🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Y S Zhao🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
- Yuqiao Zhang🇨🇳Ningxia Medical University; Ningxia Center for Diseases Prevention and Control
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Intermittent fasting (IF) is a popular dietary strategy for improving weight and cardiometabolic health. However, its effectiveness and potential risks across different adult age trajectories remain unclear. This systematic review and meta-analysis evaluated the age-specific effects of IF on body composition and cardiometabolic markers. Methods: Following PRISMA 2020 guidelines, PubMed, Scopus, and Web of Science were searched for randomized controlled trials (RCTs) up to September 2025. Participants were stratified into three cohorts: Results: Analysis of 28 RCTs (N = 1833) demonstrated that IF significantly reduced body weight and BMI across all age groups. Notably, subgroup analyses revealed comparable physiological responses between TRF and intermittent energy restriction modalities. Cardiometabolic adaptations were highly age-dependent. Young adults exhibited significant reductions in fasting insulin and HOMA-IR, alongside a robust reduction in fat mass. However, a significant loss of fat-free mass (FFM) was observed in both young and older cohorts. While middle-aged and older adults experienced the most pronounced improvements in triglycerides, systolic blood pressure, and insulin sensitivity, our conservative sensitivity analysis unmasked a significant elevation in low-density lipoprotein cholesterol (LDL-C) in this group, mirroring the robust LDL-C increase observed in young adults. Early middle-aged adults exhibited highly variable responses with no significant overall improvements in cardiometabolic parameters. Conclusions: IF is an effective weight-management tool, but elicits distinct, age-specific metabolic trajectories. While middle-aged and older adults derive pronounced cardiometabolic benefits, they face critical risks of lean mass depletion, necessitating a combined "IF+" strategy (adequate protein and resistance training). Crucially, the age-specific risk of LDL-C elevation dictates a mandate for vigilant lipid monitoring. Given that the certainty of evidence was rated as low to very low per GRADE criteria, these age-specific patterns should be interpreted as hypothesis-generating, warranting validation in future large-scale trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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