Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial
Sergeant S, Easter LH, Mustin T, Ivester P, Legins JA, Seeds MC, Standage-Beier CS, Cox A, Furdui CM, Hallmark B, Chilton FH
Nutrients · 1 cita
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- NIH HHS
- Subvenciones
- National Institutes of Health (R01-AT008621)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-04 · Nutrients · vol. 18 · número 11 · pág. 1814
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 36% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Lipid metabolism and biosynthesis
- Palabras clave
- linoleic acid, dietary linoleic acid, eicosapentaenoic acid, omega-3 fatty acids, omega-6 fatty acids, arachidonic acid, highly unsaturated fatty acids, oxylipins, lipoxygenase, n-6/n-3 ratio, inflammation, docosapentaenoic acid, eicosatetraenoic acid
- MeSH
- humans, lipoxygenase, eicosapentaenoic acid, fatty acids, unsaturated, linoleic acid, double-blind method, adult, middle aged, female, male, oxylipins, young adult, diet, western
11 autores
- Susan Sergeant🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University Health Sciences; Wake Forest University
- Linda H. Easter🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University
- Tammy Mustin🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University Health Sciences; Wake Forest University
- Priscilla Ivester🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University Health Sciences; Wake Forest University
- Jimaree A. Legins🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University Health Sciences; Wake Forest University
- Michael C. Seeds🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Carrie S. Standage‐Beier🇺🇸University of Arizona
- Anderson O. Cox🇺🇸Atrium Health Wake Forest Baptist; Wake Forest Baptist Comprehensive Cancer Center; Wake Forest University
- Cristina M. Furdui🇺🇸Atrium Health Wake Forest Baptist; Wake Forest University Health Sciences; Wake Forest University
- Brian Hallmark🇺🇸University of Arizona; BIO5 Institute
- Floyd H. Chilton🇺🇸🇲🇽University of Arizona; Tecnológico de Monterrey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
The modern Western diet (MWD) provides high linoleic acid (LA) exposure, typically contributing 6-9% of the total caloric intake. These high LA levels have fueled a longstanding debate about whether this dietary pattern confers benefit or risk. Importantly, LA intake is disproportionately elevated among lower socioeconomic populations due to greater reliance on industrial seed oils and ultra-processed foods. Despite decades of research, controlled dietary intervention studies directly evaluating the biological consequences of varying LA exposure remain limited.
Methods
The current randomized, double-blind intervention (ClinicalTrials.gov; NCT02962128; 11 November 2016) compared the effects of a 12-week Low-LA diet (2.5% energy) versus a High-LA diet (10.0% energy) in healthy adults. Outcomes included plasma concentrations of highly unsaturated fatty acids (HUFAs) and ex vivo zymosan-stimulated whole-blood oxylipin generation.
Results
Fifty-two participants completed the intervention. High LA exposure resulted in marked reductions in plasma n-3 eicosapentaenoic acid (EPA) and eicosatetraenoic acid (ETA) concentrations compared with the Low-LA arm. Docosapentaenoic acid (DPA) was also significantly lower in weeks 4 and 8. In contrast, levels of the n-6 HUFA arachidonic acid (ARA) did not differ with dietary LA exposure.
Conclusions
HUFA and oxylipin analyses revealed that higher dietary LA markedly increased the ratios of ARA to EPA and ARA- to EPA-derived oxylipin species, shifting the lipid mediator balance toward a more n-6-dominant inflammatory profile.
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