Comparison of different bromide equilibrium times to measure extracellular water in athletes: Analysis before and after a 4-day intervention to increase water intake
Jesus F, Francisco R, Kondo E, Nunes CL, Sardinha LB, Sagayama H, Schoeller DA, Silva AM
Clinical nutrition ESPEN · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação para a Ciência e a Tecnologia
- Gobierno
- Foundation for Science and Technology
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-06-12 · Clin Nutr ESPEN · vol. 75 · pág. 103398
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 43% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Body Composition Measurement Techniques · Thermoregulation and physiological responses · Electrolyte and hormonal disorders
- Palabras clave
- bromide dilution, extracellular water, equilibration time, athletes, water intake, hydration, total body water, water turnover, body composition, saliva, deuterium dilution
- MeSH
- saliva, body water, humans, bromides, longitudinal studies, body composition, drinking, time factors, female, male, young adult, athletes
8 autores
- Filipe Jesus🇵🇹 · autor de correspondenciaUniversity of Lisbon; Atlântica Instituto Universitário; Centro Interdisciplinar de Estudo da Performance Humana
- Rúben Francisco
- Emi Kondo🇯🇵Osaka University of Health and Sport Sciences
- Catarina L. Nunes🇵🇹University of Lisbon; Atlântica Instituto Universitário; Centro Interdisciplinar de Estudo da Performance Humana
- Luís Bettencourt Sardinha🇵🇹University of Lisbon; Centro Interdisciplinar de Estudo da Performance Humana
- Hiroyuki Sagayama🇯🇵University of Tsukuba
- Dale A. Schoeller🇺🇸University of Wisconsin–Madison
- Analiza M. Silva🇵🇹University of Lisbon; Centro Interdisciplinar de Estudo da Performance Humana
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Bromide (Br-) dilution is the criterion to determine extracellular water. While 3 h equilibrium is typically used in athletes, the optimal equilibrium time has not been assessed. The study aimed to determine the optimal time of equilibrium of Br- in athletes before and after increasing water intake (WI).
Methods
Thirty-one athletes [21.5 (0.8) years; 41.9% females] from the H2OAthletes randomized controlled trial (clinicaltrials.gov ID: NCT05380089) were included in this longitudinal sub-analysis. Athletes were assessed before and after a 4-day intervention to increase WI (experimental group) or maintain WI (control group). Br- dilution was assessed through saliva before and 3, 4, and 5 h post-dose. Total body water (TBW) and water turnover (rH2O) was measured through deuterium dilution. Body composition was determined through the 4-compartment model.
Results
At baseline, most athletes achieved equilibrium at 3 h (45.2%) or 4 h (48.4%). After the intervention, most athletes (70.4%) achieved peak concentration at 3 h, with fewer reaching at 4 h (14.8%) or 5 h (14.8%). No differences in body composition, TBW, or rH2O were observed between athletes grouped according to the time of peak, both before and after the intervention. Time of peak was not associated with the intervention group [x2 (1) = 1.439; p = 0.487] or sex both before [x2 (1) = 0.230; p = 0.891] and after the intervention [x2 (1) = 0.728; p = 0.695].
Conclusion
Br- equilibrium appears to occur 3 h-4 h post-dosing, suggesting it is unnecessary to extend the collection to 5 h, reducing the burden on athletes. Future studies should include larger samples to confirm the current findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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