Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical Trial
Bigolin AV, Iaroseski J, Carteri RB, Rodrigues GS, de Andrade R, De Carli LA, Razzera EL, Vian I, de Almeida da Silva R, Kalil AN, Ferreira LF
Journal of cachexia, sarcopenia and muscle · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-01 · J Cachexia Sarcopenia Muscle · vol. 17 · número 3 · pág. e70321
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 43% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutrition and Health in Aging · Fatty Acid Research and Health · Bariatric Surgery and Outcomes
- Palabras clave
- omega-3 fatty acids, EPA, docosahexaenoic acid, bariatric surgery, sarcopenia, muscle mass, grip strength, functional performance, obesity, weight loss, gastrointestinal symptoms, dietary supplementation, bioimpedance, Timed Up and Go test, postoperative fatigue, postoperative depression, postoperative anxiety
- MeSH
- humans, fatty acids, omega-3, treatment outcome, dietary supplements, adult, middle aged, female, male, bariatric surgery, sarcopenia
11 autores
- André Vicente Bigolin🇧🇷Santa Casa Hospital; Fundação Universitária de Cardiologia
- Júlia Iaroseski🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre
- Randhall Bruce Carteri🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre
- Giovanna Severino Rodrigues🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre
- Rafaela de Andrade🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre
- Luiz Alberto De Carli🇧🇷Santa Casa Hospital
- Elisa Loch Razzera🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre
- Izabele Vian🇧🇷Fundação Universitária de Cardiologia
- Roberta de Almeida da Silva🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre; Santa Casa Hospital
- Antônio Nocchi Kalil🇧🇷Universidade Federal de Ciências da Saúde de Porto Alegre; Santa Casa Hospital
- Luís Fernando Ferreira🇬🇧🇧🇷Queen's University Belfast; Universidade Federal de Ciências da Saúde de Porto Alegre; Santa Casa Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Bariatric surgery is an effective treatment for obesity but induces substantial muscle loss, potentially leading to sarcopenia. Omega-3 fatty acids have been associated with improved muscle metabolism, but their effect in the postoperative period of bariatric surgery remains unclear.
Methods
A triple-blind randomized clinical trial following CONSORT guidelines. Patients undergoing bariatric surgery were randomly assigned to receive omega-3 supplementation (2000 mg/day of EPA + DHA) or placebo (sunflower oil) for 90 days, including 15 days preoperatively and 75 days postoperatively. Assessments were performed at baseline, 45 days and 105 days after the start of supplementation. Outcomes included skeletal muscle mass (bioelectrical impedance [BIA]), handgrip strength (HGS) and functional performance (timed up and go [TUG] test).
Results
Fifty-eight patients were randomized (81% women; mean age 38.2 ± 9.9 years; mean body mass index [BMI]: 41.1 ± 4.6 kg/m2). At baseline, intervention and control groups were comparable in weight (112.7 ± 19.1 vs. 113.0 ± 17.9 kg; p = 0.946), muscle mass (33.5 ± 7.5 vs. 32.5 ± 7.3 kg; p = 0.603), HGS (33.3 ± 9.6 vs. 35.4 ± 10.2 kgf; p = 0.428) and TUG (8.7 ± 3.0 vs. 8.7 ± 1.8 s; p = 0.912). Between baseline and 105 days, muscle mass decreased significantly in both groups (-3.1 ± 0.3 kg; -2.2 ± 0.5 kg; both p < 0.001), without interaction between groups (p = 0.300). HGS remained stable (Δ -0.8 to +2.3 kgf; all p ≥ 0.364), and TUG performance did not change significantly (Δ 0.0-1.1 s; all p ≥ 0.106). Weight loss was marked in both groups (-19.3 ± 1.9 vs. -17.7 ± 2.1 kg; both p < 0.001). The incidence of gastrointestinal symptoms ≥ 3 times/week was similar (34.5% vs. 13.6% at 45 days; p = 0.114). No serious adverse events occurred.
Conclusions
Omega-3 supplementation (2000 mg/day) during the perioperative period of bariatric surgery did not prevent muscle mass loss nor improve muscle strength or functional performance within 105 days of follow-up. Although the supplementation was safe and well tolerated, it did not demonstrate efficacy in mitigating early sarcopenia-related outcomes in this population.
Trial registration
ClinicalTrials.gov: NCT06494566.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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