The effects of different forms of omega-3 polyunsaturated fatty acids on dry eye disease resulting from various etiologies: a meta-analysis and systematic review
Chen G, Yan X, Yang S, Li X
BMC ophthalmology · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Tianjin Science & Technology Foundation
- Universidad u hospital
- Open Project of the Institute of Optometry and Vision Sicense in Nankai University
- Gobierno
- Tianjin Key Medical Discipline (Specialty) Construction Project
- Gobierno
- Tianjin Science & Technology Foundation
- Subvenciones
- National Natural Science Foundation of China (82171024)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-06-16 · BMC Ophthalmol · vol. 26 · número 1
- Editorial
- BioMed Central
- Citado
- 0 citas · más que el 35% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ocular Surface and Contact Lens · Fatty Acid Research and Health · Salivary Gland Disorders and Functions
- Palabras clave
- omega-3 polyunsaturated fatty acids, dry eye, omega-3 supplementation, meibomian gland dysfunction, Sjögren's syndrome, ocular surface disease, tear film break-up time, corneal fluorescein staining
- MeSH
- tears, humans, dry eye syndromes, fatty acids, omega-3, dietary supplements, randomized controlled trials as topic
4 autores
- GuoZhen Chen🇨🇳Tianjin Medical University
- Xinlin Yan🇨🇳Nankai University
- Sin Yang🇨🇳Tianjin Medical University
- Xuan Li🇨🇳 · autor de correspondenciaNankai University; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To compare the therapeutic effects of omega-3 polyunsaturated fatty acids (PUFAs) supplements across different formulations and dry eye disease (DED) etiologies.
Methods
Studies were systematically searched in six databases without language restrictions. Dry eye symptom scores, tear break-up time (TBUT), Schirmer test, corneal fluorescein staining (CFS), and meibomian gland dysfunction (MGD) scores were extracted as outcomes. Meta-regression, sensitivity and subgroup analyses were implemented to investigate significant heterogeneity.
Results
Twenty-seven randomized controlled trials (RCTs) were included. Systemic omega-3 supplementation appeared to improve all assessed outcomes in the overall pooled analysis; however, subgroup analyses revealed formulation- and etiology-dependent effects. Among systemic long-chain omega-3 formulations, efficacy was etiology-dependent: no significant benefits were observed in MGD-associated dry eye or in cases of unspecified etiology, whereas significant improvements were found in video display terminal-related dry eye and contact lens-associated dry eye. Given the limited evidence, findings were synthesized qualitatively: omega-3 supplements demonstrated beneficial effects in rosacea-associated and Sjögren's syndrome-related dry eye, whereas no clinically meaningful improvement was observed in LASIK-induced dry eye. In contrast, neither systemic short-chain fatty acids nor the combination of long- and short-chain omega-3 PUFAs achieved statistical significance. Furthermore, topical omega-3 delivery failed to demonstrate significant benefits compared with artificial tears. Meta-regression analysis revealed a significant association between omega-3 supplementation and several external factors, including mean age, geographic location, assessment methodologies, omega-3 dose, and publication year.
Conclusions
Our research suggests that omega-3 supplements in different forms fail to demonstrate consistent effectiveness for DED of various etiological origins. Therefore, personalized guidance from healthcare providers regarding the application of omega-3 PUFAs for the management of ocular surface disorders is warranted.
Prospero registration
CRD42024623916.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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