Clinical dosimetry and efficacy of LED photobiomodulation for chronic lower-limb wound healing: a systematic review of randomized trials
Miranda MB, Barros ACS, de Paula AVL, Alves RF, da Rocha RB, Cardoso VS
Lasers in medical science · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidad u hospital
- Universidade Federal Do Delta Do Parnaíba
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-19 · Lasers Med Sci · vol. 41 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Wound Healing and Treatments · Biofield Effects and Biophysics
- Palabras clave
- diabetic foot ulcer, wound healing, irradiation parameters, energy density, wavelength, dose-response relationship, microcirculation, adjunctive therapy
- MeSH
- lower extremity, humans, diabetic foot, chronic disease, wound healing, randomized controlled trials as topic, low-level light therapy, red light
6 autores
- Mariana Bezerra MirandaUniversidade Federal do Delta do Parnaíba
- Ana Carolina Silva BarrosUniversidade Federal do Delta do Parnaíba
- Ana Vitoria Lima de PaulaUniversidade Federal do Delta do Parnaíba
- Rayana Fontenele AlvesUniversidade Federal do Delta do Parnaíba
- Rebeca Barbosa da Rocha
- Vinícius Saura Cardoso🇧🇷 · autor de correspondenciaUniversidade Federal do Delta do Parnaíba; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Chronic lower-limb wounds represent a major clinical and socioeconomic burden due to delayed healing and high recurrence rates. Light-emitting diode (LED) photobiomodulation has been proposed as a noninvasive and low-cost adjunctive therapy; however, clinical evidence remains inconsistent. This systematic review aimed to synthesize evidence from randomized clinical trials investigating the efficacy of LED photobiomodulation for chronic lower-limb wound healing and to identify irradiation parameters associated with improved outcomes. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and Embase up to May 2026. Six randomized clinical trials met the inclusion criteria. Wavelengths ranged from 620 to 950 nm, and energy densities varied between 2.4 and 126 J/cm². The findings suggest that LED photobiomodulation may promote wound area reduction, improve wound bed quality, and increase microcirculation, particularly in diabetic foot ulcers. However, one study using a high energy density (126 J/cm²) did not demonstrate beneficial effects, suggesting a possible dose-dependent response. The overall certainty of the evidence, assessed using the GRADE approach, was classified as very low due to inconsistency and indirectness among the included studies. Although LED photobiomodulation appears to be safe and demonstrates therapeutic potential, substantial heterogeneity in irradiation parameters, small sample sizes, and methodological limitations preclude definitive conclusions regarding its clinical efficacy. Well-designed randomized controlled trials with standardized protocols and dose-response investigations are needed to establish optimal therapeutic parameters and confirm clinical efficacy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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