Photobiomodulation for oral mucositis in cancer care: prevention, clinical management, and evidence from randomized controlled trials
Parra-Rojas S, Cassol-Spanemberg J, Pérez AN, Baggio GL, Velázquez-Cayón RT
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-06-19 · Support Care Cancer · vol. 34 · número 7
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 47% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, cancer patients, mucositis prevention, analgesic requirement, nutritional support, treatment parameters, supportive care
- MeSH
- humans, neoplasms, stomatitis, severity of illness index, adult, randomized controlled trials as topic, low-level light therapy
5 autores
- Susell Parra-Rojas🇪🇸Universidad Fernando Pessoa Canarias
- Juliana Cassol Spanemberg🇪🇸 · autor de correspondenciaUniversidad Fernando Pessoa Canarias
- Alejandra Navarro Pérez🇪🇸Universidad Fernando Pessoa Canarias
- Gabriela Leite BAGGIO🇧🇷🇪🇸Pontifícia Universidade Católica do Paraná; Universidad Fernando Pessoa Canarias
- Rocío Trinidad Velázquez-Cayón🇪🇸Universidad Fernando Pessoa Canarias
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This systematic review aimed to evaluate the efficacy of photobiomodulation (PBM) for the prevention and clinical management of oral mucositis (OM) in adult cancer patients, with particular emphasis on protocol characteristics potentially associated with favorable clinical outcomes.
Methods
A systematic search of PubMed, Web of Science, and Scopus was conducted up to March 31, 2026, in accordance with PRISMA guidelines. Randomized controlled trials in adult cancer patients comparing PBM with sham interventions were included. Outcomes of interest included OM incidence, severity, pain, and related clinical outcomes. The review protocol was prospectively registered in PROSPERO.
Results
Fifteen randomized controlled trials involving 868 adult patients were included. Most studies reported favorable effects of PBM, including reductions in severe OM incidence, pain intensity, analgesic requirements, and nutritional support needs compared with controls. Preventive intraoral PBM protocols were generally associated with more favorable outcomes, although variability in treatment parameters, delivery methods, and outcome reporting limited comparability. Most included studies demonstrated acceptable methodological quality.
Conclusions
PBM appears to be a promising supportive care intervention for reducing the burden of OM in adult cancer patients, particularly in preventive settings. However, variability across protocols precludes definitive conclusions regarding optimal treatment parameters. Further high-quality randomized trials with standardized reporting are needed to refine protocol recommendations and expand evidence in therapeutic settings.
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