Photobiomodulation and sleep quality: systematic review and meta-analysis
Vital de Azevedo WM, de Souza K, Defante ML, Salgado ASI, Lopes-Martins RÁB, Gomes da Silva S, Gonzalez-Lima F, Cardoso FDS
Lasers in medical science · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-20 · Lasers Med Sci · vol. 41 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 42% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photoreceptor and optogenetics research · Obstructive Sleep Apnea Research
- Palabras clave
- Neuroimaging, Sleep (system call), Meta-analysis, Randomized controlled trial, MEDLINE, Sleep deprivation, Brain stimulation
- MeSH
- mitochondria, humans, randomized controlled trials as topic, sleep wake disorders, low-level light therapy, sleep quality, red light
8 autores
- Wellington Marcos Vital de Azevedo🇧🇷Hospital São Vicente de Paulo
- Kevlin de Souza🇧🇷Hospital São Vicente de Paulo
- Maria Luiza Defante🇧🇷Hospital São Vicente de Paulo
- Afonso Shiguemi Inoue Salgado🇺🇸Quanta Technology (United States)
- Rodrigo Álvaro Brandão Lopes-Martins🇧🇷Universidade Brasil
- Sérgio Gomes da Silva🇧🇷Support group for adolescents and children with cancer
- Francisco Gonzalez-Lima🇺🇸The University of Texas at Austin
- Fabrízio dos Santos Cardoso🇧🇷 · autor de correspondenciaHospital São Vicente de Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Sleep disturbances are increasingly prevalent and associated with altered brain metabolism and neuroinflammation. Photobiomodulation, a non-invasive technique using red or near-infrared light, can modulate mitochondrial activity, cerebral perfusion, and glial function, suggesting potential benefits for sleep regulation. This systematic review and meta-analysis evaluated the effects of photobiomodulation on sleep quality in clinical and experimental populations. A comprehensive search was performed in PubMed, Embase, and Cochrane databases through September 2025 using the terms (photobiomodulation OR "low level laser therapy") AND sleep. Five randomized controlled trials involving 240 participants met inclusion criteria. The pooled analysis suggested that photobiomodulation improved the Pittsburgh Sleep Quality Index (PSQI) scores compared with sham-control (MD = - 1.25; 95% CI - 2.38 to - 0.11; p = 0.03, I2 = 36.2%), although the wide confidence intervals indicate limited precision of the estimate. Mechanistic and neuroimaging evidence supports that PBM enhances mitochondrial metabolism, modulates astrocytic activity, and reorganizes prefrontal networks involved in sleep regulation. Despite methodological heterogeneity among studies, these findings suggest that photobiomodulation may have potential as a non-pharmacological approach for improving sleep quality; however, the current evidence remains limited and should be interpreted with caution. Further large-scale, standardized, and multimodal trials are required to establish optimal stimulation parameters and confirm long-term efficacy and safety.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.