Efficacy of 8% arginine associated with low-level laser therapy in the treatment of dentin hypersensitivity: randomized double-blind clinical trial
Leal Barbosa V, Westenhofen D, Scherdien Silva P, Zimmer R, Rivera Oballe H, Quevedo Miguens Júnior SA, Galia Reston E
Lasers in medical science · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidad u hospital
- Pontifícia Universidade Católica do Rio Grande do Sul
- Subvenciones
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ((Code 001))
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-20 · Lasers Med Sci · vol. 41 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 43% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dental Erosion and Treatment · Laser Applications in Dentistry and Medicine · Dental Health and Care Utilization
- Palabras clave
- dentin hypersensitivity, low-level laser therapy, tactile sensitivity, combination therapy, dental pain
- MeSH
- humans, dentin sensitivity, arginine, pain measurement, treatment outcome, combined modality therapy, double-blind method, adult, middle aged, female, male, young adult, dentin desensitizing agents, low-level light therapy
7 autores
- Viviane Leal Barbosa🇧🇷Universidade Luterana do Brasil
- Djuly Westenhofen🇧🇷Universidade Luterana do Brasil
- Paola Scherdien Silva🇧🇷Universidade Luterana do Brasil
- Reinhold Zimmer🇧🇷 · autor de correspondenciaPontifícia Universidade Católica do Rio Grande do Sul; Universidade Luterana do Brasil
- Harry Juan Rivera Oballe🇧🇷Universidade Federal de Pelotas; Universidade Luterana do Brasil
- Sérgio Augusto Quevedo Miguens🇧🇷Universidade Luterana do Brasil
- Eduardo Galia Reston🇧🇷Universidade Luterana do Brasil
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH).
Materials and methods
This randomized, double-blind, parallel-group clinical trial included participants with DH who were allocated into four groups: laser group (LG), arginine group (AG), combined laser and arginine group (LAG), and control group (CG). Clinical assessments were performed at baseline and after 2, 4, and 8 weeks. DH was evaluated using evaporative (air stimulus) and tactile tests applied to the cervical-buccal surface of the teeth, with pain intensity recorded using the Visual Analog Scale (VAS). Linear mixed-effects models were used for longitudinal continuous outcomes (Schiff and VAS scores), while generalized estimating equations were applied for tactile sensitivity outcomes, adopting a significance level of 5%.
Results
A total of 60 participants were enrolled, and 54 completed the study. A significant reduction in DH was observed over time for both Schiff scores and VAS values (p 0.05).
Conclusions
All evaluated therapies were effective in reducing DH over the 8-week follow-up period, with a progressive reduction in symptoms over time. However, no statistically significant differences were observed between the interventions, and no additive effect was identified for the combined therapy.
Clinical trial registration
Brazilian Clinical Trials Registry ReBEC; RBR2vxzvkz, October 13th, 2023.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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