Effect of a pro-fertility diet combined with omega-3 supplementation on embryo quality in infertile women undergoing IVF: a randomized controlled trial
Ghadimi Yari M, Ghasemi-Tehrani H, Feizi A, Ziaei R, Derakhshan M, Rouhani MH
Reproductive biomedicine online · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-02-27 · Reprod Biomed Online · vol. 53 · número 3 · pág. 105661
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 92% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Reproductive Health and Technologies · Reproductive Biology and Fertility · Assisted Reproductive Technology and Twin Pregnancy
- Palabras clave
- omega-3 supplementation, embryo quality, fertilization rate, female infertility, in vitro fertilization, vitamin D, folic acid, vitamin B12, dietary intervention, embryo quality assessment
- MeSH
- humans, infertility, female, folic acid, fatty acids, omega-3, fertilization in vitro, diet, pregnancy rate, single-blind method, pregnancy, dietary supplements, adolescent, adult, iran, female, young adult
6 autores
- Mahnaz Ghadimi🇮🇷Isfahan University of Medical Sciences
- Hatav Ghasemi Tehrani🇮🇷Isfahan University of Medical Sciences
- Awat Feizi🇮🇷Isfahan University of Medical Sciences
- Rahele Ziaei🇮🇷Isfahan University of Medical Sciences
- Marzieh Derakhshan🇮🇷Isfahan University of Medical Sciences
- Mohammad Hossein Rouhani🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Research question
Does adherence to a pro-fertility diet (PFD) combined with omega-3 supplementation improve the fertilization rate and embryo quality in infertile women undergoing IVF?
Design
A randomized, single-blind, parallel clinical trial was conducted from June 2024 to June 2025 among 180 infertile women aged 18-42 years undergoing IVF at Hazrat Maryam Fertility Center, Isfahan, Iran. Participants were randomized (1:1) to receive either a structured PFD with daily omega-3 (1000 mg), vitamin D (1000 IU), folate (1 mg) and vitamin B12 (500 µg) supplementation for 60 days, or general dietary advice based on the Healthy Eating Plate model plus 500 µg/day folic acid. Fertilization rate, embryo formation rate and embryo quality (grades A-D) were evaluated.
Results
Compared with controls, the intervention group had significantly higher fertilization rates (0.81 ± 0.16 versus 0.66 ± 0.24; P < 0.001) and embryo formation rates (0.79 ± 0.26 versus 0.62 ± 0.30; P < 0.001), and an increased number of embryos formed (3.78 ± 2.34 versus 2.22 ± 1.46; P < 0.001). Additionally, the proportion of grade A embryos was markedly higher in the intervention group (45.2% versus 21.7%; P = 0.003).
Conclusion
Adherence to a PFD combined with omega-3 supplementation significantly improved the fertilization rate and embryo quality in women undergoing IVF. This combined nutritional intervention represents a safe, feasible and cost-effective adjunctive approach to optimize embryological outcomes in assisted reproductive technology.
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