The effects of vitamin D supplementation on inflammatory biomarkers: an umbrella study of meta-analysis on randomized controlled trials
Hsu CY, Hussein HY, Al-Akkam KA, Gajjar TB, AlMohamadi H, Khonturaev N, Shukla SK, Radhi SH, Smerat A, Iqbal MS
Inflammopharmacology · 0 citas
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- The Research, Development, and Innovation Authority (RDIA) - Kingdom of Saudi Arabia
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-06-24 · Inflammopharmacology · vol. 34 · número 7 · págs. 4297–4310
- Editorial
- Springer Nature
- Citado
- 0 citas · más que el 47% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Antioxidant Activity and Oxidative Stress · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, inflammatory markers, oxidative stress, C-reactive protein, TNF-α, interleukin-6, type 2 diabetes, obesity, asthma, pregnancy, metabolic disorders, anti-inflammatory activity, glutathione, malondialdehyde, total antioxidant capacity, IL-10, IL-1β, interleukin-8, IgE, glucose homeostasis
- MeSH
- humans, inflammation, vitamin d, oxidative stress, dietary supplements, meta-analysis as topic, randomized controlled trials as topic, biomarkers
10 autores
- Chou-Yi Hsu
- Hassan Youssef Hussein🇮🇶University of Al Maarif
- Karam Akram Al‐Akkam🇮🇶University of Kerbala
- Tushar B. Gajjar
- Hamad Almohamadi🇸🇦 · autor de correspondenciaIslamic University of Madinah
- Хонтураев Нодир🇺🇿Jizzakh State Pedagogical University
- Sandeep Kumar Shukla🇮🇳Sharda University
- Safa Hussien Radhi🇮🇶🇮🇳Islamic University of Najaf; Chitkara University
- Aseel Smerat🇯🇴🇮🇳Al-Ahliyya Amman University; Saveetha University
- Muhammad Shahid Iqbal🇸🇦Prince Sattam Bin Abdulaziz University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D regulates bone metabolism and immune function, influencing inflammatory biomarkers such as CRP, TNF-α, and IL-6. Evidence from RCTs and meta-analyses on its anti-inflammatory effects remains inconsistent. To synthesize evidence from meta-analyses of RCTs on vitamin D supplementation and its effects on circulating inflammatory biomarkers, and to assess the quality and certainty of this evidence.
Methods
A comprehensive literature search was conducted in PubMed, Embase, Web of Science, and Scopus from inception to January 2025. Eligible studies included systematic reviews and meta-analyses of RCTs reporting effects of vitamin D supplementation on inflammatory markers (CRP, hs-CRP, TNF-α, IL-1β, IL-6, IL-8, IL-10, oxidative stress markers, IgE). Data extraction was performed independently by two reviewers. Methodological quality was assessed using AMSTAR-2, and the certainty of evidence was graded with GRADE. Corrected Covered Area (CCA) was calculated to quantify overlap among primary studies.
Results
This umbrella review analyzed seven meta-analyses covering 97 RCTs with ~ 11,600 participants on vitamin D supplementation's effects on inflammation and oxidative stress markers. Vitamin D significantly reduced CRP, TNF-α, and IL-6 levels in individuals with abnormal glucose homeostasis (Hedges'g = - 0.67, - 0.81, and - 1.93, respectively; p < 0.001), and improved oxidative stress markers in pregnant women, evidenced by decreased MDA (Hedges'g = - 0.46) and increased TAC (Hedges'g = 2.13) and glutathione (Hedges'g = 4.37). In type 2 diabetes, a significant reduction in hs-CRP (Hedges'g = - 0.45, p = 0.005) and TNF-α (Hedges'g = - 0.75, p = 0.05) was observed. Conversely, studies in obese/overweight and asthmatic populations revealed no significant changes in inflammatory markers, except for a highly heterogeneous and potentially unreliable increase in IL-10 among asthma patients (Hedges'g = 18.85, p = 0.04).
Conclusions
Vitamin D supplementation exerts significant anti-inflammatory and antioxidant effects, particularly in metabolic disorders, though evidence remains heterogeneous across populations and biomarkers.
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