Higher Maternal Body Mass Index Attenuates the Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the Randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART)
Jung C, Lu Z, Handy DE, Litonjua AA, Loscalzo J, Weiss ST, Mirzakhani H
The Journal of nutrition · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Heart Lung and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL091528); National Heart, Lung, and Blood Institute (1K01HL146977-01A1); National Heart, Lung, and Blood Institute (U03 HL091528)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2026-06-25 · J Nutr · vol. 156 · número 9 · pág. 101688
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 47% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Pregnancy and Medication Impact
- Palabras clave
- vitamin D supplementation, pregnancy, maternal body mass index, 25-hydroxyvitamin D, high-dose vitamin D, obesity, overweight, treatment response, dose-response relationship
- MeSH
- humans, asthma, pregnancy complications, vitamin d deficiency, vitamin d, body mass index, double-blind method, pregnancy, dietary supplements, adult, female
7 autores
- Catherine Jung🇺🇸Brigham and Women's Hospital; Harvard University
- Zheng Lu🇺🇸Brigham and Women's Hospital; Harvard University
- Diane E. Handy🇺🇸Brigham and Women's Hospital; Harvard University
- Augusto A. Litonjua🇺🇸Golisano Children's Hospital
- Joseph Loscalzo🇺🇸Brigham and Women's Hospital; Harvard University
- Scott T. Weiss🇺🇸Brigham and Women's Hospital; Harvard University
- Hooman Mirzakhani🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D supplementation during pregnancy is recommended to optimize maternal vitamin D status, yet biochemical response is highly variable, potentially limiting attainment of adequate 25-hydroxyvitamin D [25(OH)D] concentrations. Maternal body mass index (BMI) may modify vitamin D response, but this relationship has not been comprehensively examined in randomized trials conducted during pregnancy.
Objectives
This study examines whether maternal BMI modifies the biochemical response to high-dose vitamin D supplementation during pregnancy.
Methods
Using data from the vitamin D antenatal asthma reduction trial, a randomized, double-blind trial of pregnant participants, we examined whether maternal BMI modifies response to high-dose (110 μg/d) compared with standard-dose (10 μg/d) vitamin D supplementation. Maternal serum 25(OH)D was measured at enrollment (10‒18 wk) and in the third trimester (32‒38 wk). Linear mixed-effects models examined the interaction between treatment group and BMI (categories <25, 25‒29.9, and ≥30; continuous; and ordinal), adjusting for baseline 25(OH)D and demographic and clinical covariates.
Results
Among 816 participants in the intention-to-treat analysis, high-dose supplementation increased maternal 25(OH)D by 22.43 nmol/L [95% confidence interval (CI): 17.16, 27.70 nmol/L; P 2. This treatment effect was attenuated with higher BMI: by 8.39 nmol/L (95% CI: -16.46, -0.32 nmol/L; P = 0.041) in the overweight group (BMI 25‒29.9 kg/m2) and 8.63 nmol/L (95% CI: -16.06, -1.20 nmol/L; P = 0.023) in the obese group (BMI ≥30 kg/m2), representing 37% and 38% reductions in treatment effect, respectively. Modeled continuously, each 1 kg/m2 increase was associated with a 0.45 nmol/L reduction in treatment effect (95% CI: -0.86, -0.03 nmol/L; P = 0.035). Sensitivity analyses using change-score models and prepregnancy BMI yielded consistent results.
Conclusions
Maternal BMI attenuates the biochemical response to vitamin D supplementation during pregnancy in a graded, BMI-dependent manner. Although most participants receiving 110 μg/d achieved 25(OH)D concentrations ≥50 nmol/L, higher BMI was associated with a smaller increase in 25(OH)D and a greater likelihood of remaining below the higher 75 nmol/L target. These findings suggest that uniform prenatal supplementation strategies may not fully account for BMI-related differences in vitamin D response. Future studies should determine whether BMI-stratified dosing improves achieved vitamin D status and translates into better maternal or offspring outcomes. This trial was registered at clinicaltrials.gov as NCT00920621.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.