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Metaanálisis2026Financiación no declarada

Synergy or Dominance? The Ergogenic Effects of Caffeine and Carbohydrate on High-Intensity Interval Exercise Performance: A Three-Level Meta-Analysis

Li H, Peng Y, Liu B, Ding L, Xu K, Lei TH, Gong B, Cao Y

Nutrients · 0 citas

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Cómo se estudió

Diseño
Metaanálisis (indexado por PubMed)
Estudiado en
Personas
Resultado principal
Marcadores de salud y funcionamiento

Quién lo pagó

Financiación
Financiación no declarada

Publicación

Publicado
2026-06-10 · Nutrients · vol. 18 · número 12 · pág. 1868
Editorial
Multidisciplinary Digital Publishing Institute
Citado
0 citas · más que el 45% de estudios similares · 0.0× el promedio de su campo
Referencias
64 trabajos
Acceso
Acceso abierto (revista) · CC-BY
Áreas de investigación
Coffee research and impacts · Sports Performance and Training · Muscle metabolism and nutrition
Palabras clave
caffeine, carbohydrates, high-intensity interval exercise, ergogenic aids, mouthwash, carbohydrate intake, exercise performance, training status, sex differences
MeSH
humans, caffeine, dietary carbohydrates, female, male, randomized controlled trials as topic, athletic performance, performance-enhancing substances, high-intensity interval training

8 autores

  • Hao Li🇨🇳Shanghai University of Sport
  • Yixiang Peng🇲🇴Macao Polytechnic University
  • Baiyu Liu🇨🇳Shanghai Normal University
  • Li Ding🇨🇳Shanghai University of Sport
  • Kai Xu🇨🇳Shanghai University of Sport
  • Tze‐Huan Lei🇨🇳Hubei Normal University
  • Bomin Gong🇨🇳Shanghai University of Traditional Chinese Medicine
  • Yinhang Cao🇨🇳Shanghai University of Sport

Resumen

El texto original del estudio, en el idioma en que se publicó.

Background/Objectives: This meta-analysis aimed to quantify the combined ergogenic effects of caffeine (CAF) and carbohydrate (CHO) on high-intensity interval exercise (HIIE) performance and to identify potential moderating factors. Methods: Four databases were systematically searched to identify randomized crossover trials assessing CAF combined with CHO (CAF + CHO) on HIIE performance (i.e., exercise time, distance, or total work). A three-level random-effects meta-analysis was performed to calculate pooled Hedge's g (g) values. Moderator effects were explored through subgroup analyses, including control group (placebo-, CHO-, and CAF-controlled), CHO administration (mouth rinse and ingestion), and training status (recreationally active and trained). Results: Eleven studies met the inclusion criteria (n = 105; 8 female). CAF + CHO significantly enhanced HIIE performance (g = 0.44, 95% CI: 0.23-0.66). Subgroup analyses indicated that CAF + CHO mouth rinsing (g = 0.91, CI: 0.49-1.33) yielded superior effects compared to CAF + CHO ingestion (g = 0.33, CI: 0.14-0.52) (p for subgroup p for subgroup > 0.05). Importantly, evidence of publication bias was identified, and the overall certainty of evidence was graded as low according to the GRADE framework. Conclusions: CAF + CHO appears to be effective for enhancing HIIE performance, with greater benefits observed when CHO is administered via mouth rinsing rather than ingestion. Preliminary evidence suggests that CAF may play a key role in CAF + CHO strategies. However, given the limited number of female participants, the generalizability of these findings to both sexes is limited. Additional high-quality trials are needed to establish more definitive recommendations.

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