Dose-Response Effect of Oral Caffeine Use on Aerobic Exercise Performance: A Systematic Review and Meta-Analysis
Martins GL, Aparecido JM, Marquezi ML, Frientes CS, Miedes LR, Fornel MS, Fernandes T, Lancha AH
Nutrients · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- National Council for Scientific and Technological Development
- Gobierno
- Brazilian Federal Agency for Support and Evaluation of Graduate Education
- Gobierno
- São Paulo Research Foundation
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (#302706/2020-8); Conselho Nacional de Desenvolvimento Científico e Tecnológico (#312628/2023-4); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.357773/2019-00.); Conselho Nacional de Desenvolvimento Científico e Tecnológico (409629/2021-9); Fundação de Amparo à Pesquisa do Estado de São Paulo (23/14680-5); Conselho Nacional de Desenvolvimento Científico e Tecnológico (408899/2024‐7); Conselho Nacional de Desenvolvimento Científico e Tecnológico (437801/2018-7); Fundação de Amparo à Pesquisa do Estado de São Paulo (22/03138-2)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2024-10-01 · Nutrients · vol. 18 · número 10S · pág. 1989
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 0 citas
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Pharmacology and Obesity Treatment
- Palabras clave
- Meta-analysis, Aerobic exercise, Caffeine, Medicine, Physical therapy, Psychology, Internal medicine
- MeSH
- humans, caffeine, exercise, administration, oral, dose-response relationship, drug, adolescent, adult, middle aged, female, male, randomized controlled trials as topic, athletic performance, young adult, performance-enhancing substances
8 autores
- Gabriel Loureiro Martins
- Juliana Monique Lino Aparecido🇧🇷Universidade Cidade de São Paulo
- Marcelo Luís Marquezi🇧🇷Universidade Cidade de São Paulo
- Caroline Santana Frientes🇧🇷Universidade Cidade de São Paulo
- Leonardo Ribeiro Miedes🇧🇷Universidade Cidade de São Paulo
- Matheus Silva Fornel🇧🇷Universidade Cidade de São Paulo
- Tiago Menezes Fernandes🇧🇷Universidade de São Paulo
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objective: Caffeine has demonstrated ergogenic effects across various doses (2-9 mg·kg-1). However, aerobic responses to caffeine vary substantially, with time-trial performance ranging from ~-3% to +16%. Given that higher doses may increase adverse effects without clear additional benefits, this review examined the effects of low (≤3 mg·kg-1), moderate (4-6 mg·kg-1), and high (>6 mg·kg-1) caffeine doses on time-trial performance. Methods: A systematic review and meta-analysis of randomized, placebo-controlled trials was conducted using PubMed, Embase, and Virtual Health Library databases. Eligible studies included healthy adults (18-59 years) acutely ingesting oral anhydrous caffeine before aerobic time-trial tests, with performance outcomes measured exclusively as time-to-completion variables. Data were pooled using standardized mean differences (SMDs) and 95% confidence intervals under random-effects models, and risk of bias was assessed using the Cochrane Risk of Bias tool. Results: Forty-eight studies (689 participants) met the inclusion criteria. Both low and moderate caffeine doses significantly reduced time-trial completion time relative to placebo. Low doses produced a standardized mean difference of -0.27 (95% CI: -0.44 to -0.11; p = 0.001), whereas moderate doses resulted in an SMD of -0.52 (95% CI: -0.77 to -0.28; p 6 mg·kg-1) and reporting time-to-completion outcomes met the inclusion criteria. Subgroup analyses demonstrated similar ergogenic effects in both trained and highly trained individuals consuming moderate caffeine doses. Conclusions: This is the first meta-analysis specifically focused on aerobic time-trial performance to suggest that pre-exercise ingestion of low caffeine doses (1.3-3 mg·kg-1) may enhance endurance performance by reducing time-trial completion time. Notably, the use of moderate caffeine doses (4-6 mg·kg-1) appears to produce a more consistent ergogenic effect.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.