Effect of two types of time-restricted eating on glycemic, lipid indices, and weight in women with polycystic ovary syndrome: a randomized controlled trial
Aminian M, Hajshafiha M, Heidari M, Daneghian S
European journal of nutrition · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-06-29 · Eur J Nutr · vol. 65 · número 5
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Ovarian function and disorders · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- time-restricted eating, polycystic ovary syndrome, glycemic control, insulin resistance, fasting insulin, lipid profile, body weight, waist circumference, dietary intervention, women
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, body weight, insulin, blood glucose, lipids, body mass index, fasting, glycemic index, adult, female, waist circumference, young adult, intermittent fasting
4 autores
- Maryam Aminian🇮🇷Urmia University of Medical Sciences
- Masoumeh Hajshafiha🇮🇷Urmia University; Urmia University of Medical Sciences
- Mohammad Heidari🇮🇷Urmia University; Urmia University of Medical Sciences
- Sevana Daneghian🇮🇷 · autor de correspondenciaUrmia University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder among women of reproductive age with significant metabolic impairments. Time-restricted eating (TRE) has emerged as a promising dietary strategy for improving metabolic health. Although both early time-restricted eating (eTRE) and mid-day time-restricted eating (mTRE) have shown beneficial metabolic effects, their comparative efficacy in women with PCOS remains unclear. This study aimed to directly compare the effects of eTRE and mTRE on glycemic control, lipid profiles, and anthropometric outcomes in women with PCOS.
Methods
In this 6-week randomized controlled trial, 75 women with PCOS were allocated to one of three groups: eTRE (8:00 AM-6:00 PM), mTRE (11:00 AM-9:00 PM), or a control group with ad libitum eating. The primary outcome was fasting insulin level. Secondary outcomes included FBS, insulin resistance indices, lipid profile (total cholesterol (TC), LDL-C, HDL-C, and TG), body weight, BMI, waist circumference (WC), and dietary intake. Metabolic and anthropometric variables were assessed at baseline and post-intervention, while dietary intake was evaluated at baseline, mid-intervention, and study completion.
Results
Both eTRE and mTRE significantly reduced FBS, fasting insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), body weight, and WC compared with the control group (P < 0.05). Additionally, eTRE significantly improved TC (P < 0.001) and LDL-C levels (P = 0.01), whereas similar changes were not observed in the mTRE group.
Conclusion
TRE, particularly eTRE, appears to be an effective dietary intervention for women with PCOS, offering significant benefits for glycemic control, metabolic health, and weight management.
Trial registration
IRCT20221122056575N1.
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