Serum vitamin D levels in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis
Jiang M, Wang T, Huang L
Frontiers in endocrinology · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundamental Research Funds for the Central Universities
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-06-16 · Front Endocrinol (Lausanne) · vol. 17 · pág. 1839319
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 40% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ovarian function and disorders · Vitamin D Research Studies · Menstrual Health and Disorders
- Palabras clave
- Polycystic ovary, Vitamin D and neurology, vitamin D deficiency, Obesity, Meta-analysis, Insulin resistance, Prospective cohort study, Insulin sensitivity
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, vitamin d deficiency, obesity, vitamin d, female
3 autores
- Mei Jiang🇨🇳Beijing University of Chinese Medicine
- Tan Wang🇨🇳Beijing University of Chinese Medicine
- Ling Huang🇨🇳 · autor de correspondenciaBeijing University of Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Vitamin D deficiency is linked to increased risk of polycystic ovary syndrome (PCOS) and may worsen metabolic disorders such as insulin resistance. However, evidence remains inconsistent regarding vitamin D status in non-obese women with PCOS. This study aimed to perform the first systematic review and meta-analysis evaluating serum vitamin D levels in non-obese PCOS patients.
Methods
Relevant studies were searched in PubMed, Embase, Cochrane Library, and Web of Science up to May 2025. Eligible studies comparing non-obese PCOS women and healthy controls were included. Two reviewers independently screened articles. Meta-analysis was conducted using a random-effects model, supplemented by subgroup, sensitivity, and publication bias analyses.
Results
Eleven studies involving 533 non-obese PCOS patients and 574 controls were included. No significant differences were found in serum 25(OH)D or 1,25(OH)2D levels between groups. Heterogeneity was mainly attributed to region, diagnostic criteria, BMI, and assay methods. Significant publication bias was detected.
Discussion
Serum vitamin D levels are not significantly associated with non-obese PCOS, implying vitamin D deficiency may be driven by obesity rather than PCOS pathogenesis. Vitamin D supplementation may benefit obese PCOS patients, and further prospective studies are needed.
Systematic review registration
http://www.crd.york.ac.uk/PROSPERO, identifier CRD420251168257.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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