Does creatine supplementation improve strength and power in physically active individuals on a vegan diet? a randomized, triple-blind, placebo-controlled trial
López-Moreno M, Muñoz A, Aguilar-Navarro M, Gutiérrez-Hellín J, Franco-Andrés A, López-López P, Crespo-Cañizares A, Marrero-Fernández P, Forbes SC
European journal of applied physiology · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidad Francisco de Vitoria
- Subvenciones
- Universidad Francisco de Vitoria (AGL-2024-46)
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-07-02 · Eur J Appl Physiol · vol. 126 · número 10 · págs. 5521–5532
- Editorial
- Springer Science+Business Media
- Citado
- 2 citas · más que el 96% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Sports Performance and Training · Biochemical effects in animals
- Palabras clave
- creatine monohydrate supplementation, vegan diet, muscle strength, muscle power, countermovement jump, grip strength, isometric mid-thigh pull, body composition, skeletal muscle mass, serum creatinine, renal biomarkers, physically active adults
- MeSH
- muscle, skeletal, humans, creatine, body composition, dietary supplements, adolescent, adult, middle aged, female, male, muscle strength, young adult, diet, vegan
9 autores
- Miguel López‐Moreno🇪🇸Universidad Francisco de Vitoria
- Alejandro Muñoz🇪🇸 · autor de correspondenciaUniversidad Francisco de Vitoria
- Millán Aguilar‐Navarro🇪🇸Universidad Francisco de Vitoria
- Jorge Gutiérrez‐Hellín🇪🇸Universidad Francisco de Vitoria
- Arturo Franco-Andrés🇪🇸Universidad Francisco de Vitoria
- Pilar López-López🇪🇸Universidad Francisco de Vitoria
- Almudena Crespo-Cañizares🇪🇸Universidad Francisco de Vitoria
- Paula Marrero‐Fernández🇪🇸Universidad de La Laguna; Universidad Francisco de Vitoria
- Scott C. Forbes🇨🇦Brandon University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study aimed to assess the impact of four weeks of creatine monohydrate supplementation on strength and power performance in physically active individuals following a vegan diet.
Methods
Twenty physically active vegan adults (18-45 years) were enrolled in a triple-blind, placebo-controlled study. Participants were randomly assigned to receive either creatine monohydrate (0.1 g·kg⁻¹·day⁻¹; 5 females and 5 males) or a placebo (5 females and 5 males), while adhering to a normocaloric vegan diet. Body composition, physical performance (countermovement jump test (CMJ), sprint, repeated jumps, handgrip strength, and isometric mid-thigh pull), and renal biomarkers were assessed at baseline and after a 4-week supplementation period.
Results
After 4 weeks, the creatine group showed significant increases in skeletal muscle mass (+ 0.3 kg), total body water (+ 1.4 kg), and BMI (+ 0.3 kg/m²), along with reduced body fat (-1.4 kg) compared to controls (p < 0.05). Serum creatinine and creatine levels significantly increased in the creatine group (p < 0.001-0.03). Performance improvements were observed in lower-body explosive performance, particularly in CMJ, as well as in maximal height and flight time during repeated jumps (p < 0.001-0.04), with no changes in sprint or strength tests.
Conclusion
Four weeks of creatine supplementation in individuals following a vegan diet enhances muscle strength and lower-body muscular power. Longer-term studies are needed to confirm the effectiveness and safety of creatine supplementation in this population.
Trial registration
NCT06483321. https//clinicaltrials.gov/study/NCT06483321.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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