Fish oil-derived fatty acids during pregnancy and risk of neurodevelopmental disorders in children at age 10 - A randomized controlled trial
Rosenberg JB, Sevelsted A, Jepsen JRM, Vinding R, Mohammadzadeh P, Hernández Lorca M, Horner D, Sørensen ME, Fagerlund B, Bilenberg N, Pantelis C, Glenthøj BY, Chawes B, Stokholm J, Ebdrup BH, Bønnelykke K
Translational psychiatry · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Organización sin fines de lucro
- Lundbeckfonden
- Gobierno
- Horizon 2020 Framework Programme
- Gobierno
- EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
- Empresa
- Lundbeckfonden (Lundbeck Foundation)
- Subvenciones
- Lundbeckfonden (R269‐2017‐5); Horizon 2020 Framework Programme (946228)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-02 · Transl Psychiatry · vol. 16 · número 1
- Editorial
- Springer Nature
- Citado
- 0 citas · más que el 45% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 1 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Maternal Mental Health During Pregnancy and Postpartum
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, pregnancy, neurodevelopmental disorders, attention deficit hyperactivity disorder, autism spectrum disorder, autistic traits, child psychopathology
- MeSH
- humans, prenatal exposure delayed effects, docosahexaenoic acids, eicosapentaenoic acid, fish oils, attention deficit disorder with hyperactivity, pregnancy, dietary supplements, adult, child, female, male, neurodevelopmental disorders
16 autores
- Julie Bøjstrup Rosenberg🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Astrid Sevelsted🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Jens Richardt M. Jepsen🇩🇰University of Copenhagen; Mental Health Services; Copenhagen University Hospital
- Rebecca Vinding🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Parisa Mohammadzadeh🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- María Hernández‐Lorca🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- David Horner🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Mikkel E. Sørensen🇩🇰University of Copenhagen
- Birgitte Fagerlund🇩🇰University of Copenhagen; Mental Health Services; Copenhagen University Hospital
- Niels Bilenberg🇩🇰University of Southern Denmark; Region of Southern Denmark
- Christos Pantelis🇦🇺The University of Melbourne; Melbourne Health
- Birte Yding Glenthoj🇩🇰University of Copenhagen
- Bo Chawes🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Jakob Stokholm🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Bjørn Hylsebeck Ebdrup🇩🇰University of Copenhagen
- Klaus Bønnelykke🇩🇰University of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
Resumen
El texto original del estudio, en el idioma en que se publicó.
Fish oil-derived omega-3 fatty acids (ꙍ-3 FA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are critical for early brain development, but evidence of causal effects from supplementation during pregnancy is limited. In the prospective COPSAC2010 cohort of 700 mother-child pairs, we investigated whether i) maternal DHA + EPA blood concentrations in mid-pregnancy and ii) fish oil supplementation in a randomized trial in late pregnancy influence neurodevelopmental outcomes at age 10. Maternal blood DHA + EPA concentrations were measured at 24 weeks gestation, followed by randomization to 2.4 g daily fish oil (37% DHA, 55% EPA) or placebo until one-week postpartum. Psychopathology was assessed in the children at age 10 using the Kiddie Schedule for Affective Disorders and Schizophrenia -Present and Lifetime version and parental-rated questionnaires Statistical analyses included logistic and linear regression models. Higher maternal DHA + EPA concentrations were associated with reduced ADHD risk (OR 0.71, p = 0.03) and ADHD symptom load (β = -1.14, p < 0.001) in unadjusted analyses but not after confounder adjustment (OR 0.82, p = 0.24; β = -0.49, p = 0.21). Similar trends were observed for autistic traits (β = -1.96, [-1.11; -0.24] p = 0.01), but not significant after confounder adjustment. Fish oil supplementation showed no significant reduction in ADHD (OR 0.79, p = 0.37) or ASD risk (OR 0.56, p = 0.42). A secondary analysis suggested a protective effect for ADHD Predominantly Inattentive Presentation, although it did not hold significance after correction for multiple testing (OR 0.41; p = 0.03; FDRp=0.12). Thus, potential effects on inattentive ADHD symptoms should be explored in future studies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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