The Efficacy of Individualized Music Therapy in Patients With MCS: A Pilot Study on EEG
Zhang X, Wang Y, Talifu Z, Feng Q, Gu J, Li X, Du X
Neural plasticity · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Sin clasificar
- Capital Funds for Health Improvement and Research
- Subvenciones
- National Natural Science Foundation of China (T2341003)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-01-01 · Neural Plast · vol. 2026 · número 1 · pág. e8832006
- Editorial
- Hindawi Publishing Corporation
- Citado
- 0 citas · más que el 53% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Music Therapy and Health · Traumatic Brain Injury Research · Neuroscience and Music Perception
- Palabras clave
- minimally conscious state, alpha power, Coma Recovery Scale-Revised, neurorehabilitation, treatment safety and feasibility
- MeSH
- humans, persistent vegetative state, electroencephalography, treatment outcome, music therapy, pilot projects, single-blind method, adult, aged, middle aged, female, male
7 autores
- Xiaoying Zhang🇨🇳Capital Medical University; China Rehabilitation Research Center
- YunLei Wang🇨🇳Capital Medical University; China Rehabilitation Research Center
- Zuliyaer Talifu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Qingqing Feng🇨🇳Capital Medical University; China Rehabilitation Research Center
- Jiayi Gu🇨🇳Hunan Normal University; Hunan Provincial People's Hospital
- Xiaobing Li🇨🇳Central Conservatory of Music
- Xiaoxia Du🇨🇳Capital Medical University; China Rehabilitation Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the feasibility, safety, and preliminary effects of individual music therapy (IMT) on electroencephalography (EEG) cortical activation in patients with minimally conscious state (MCS).
Design
This study was pilot randomized, single-blind, and blank-controlled trial.
Setting
China Rehabilitation Research Center (CRRC), Beijing, China.
Participants
Sixty-two MCS patients (diagnosed by Coma Recovery Scale-Revised [CRS-R]) were enrolled between March 2024 and July 2025; 43 completed the trial and were randomized.
Intervention
The experimental group (n = 22) received 12-week individualized music therapy (30-min sessions, five times per week) delivered by a certified music therapist.
Comparator
The control group (n = 21) received routine treatment and rehabilitation training without music intervention.
Primary outcome
The change in EEG spectral power (alpha band, 8-13 Hz) over right-hemisphere frontocentral regions from baseline (T1) to post-intervention (T2).
Results
The IMT group showed significantly increased alpha power over the right lateral prefrontal cortex, precentral gyrus, and central sulcus at T2 compared T1 (p < 0.05; descriptive comparison), whereas no such change was observed in the control group. No adverse events occurred in either group.
Conclusion
IMT is feasible and safe in medically fragile MCS patients and may induce right-hemisphere cortical activation. These pilot findings are hypothesis-generating and require confirmation in larger, adequately powered trials.
Trial registration
Chinese Clinical Trial Registry: ChiCTR2500114153, MR-11-24-014167.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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