Photobiomodulation with or without ILIB in diabetic peripheral neuropathy: a randomized pilot trial
de Alencar Fonseca Santos J, de Souza Maciel Ferreira JE, da Silva Galvão JW, de Oliveira Lima A, de Almeida ECS, Lukelo LA, Pereira GA, de Araújo TM
Lasers in medical science · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidade Da Integracao Internacional Da Lusofonia Afro Brasileira
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-10 · Lasers Med Sci · vol. 41 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Pain Mechanisms and Treatments · Pain Management and Treatment
- Palabras clave
- low-level laser therapy, intravascular laser irradiation of blood, diabetic peripheral neuropathy, neuropathic pain, non-pharmacological pain management, sensory symptoms
- MeSH
- humans, neuralgia, diabetic neuropathies, pain measurement, treatment outcome, combined modality therapy, prospective studies, pilot projects, aged, middle aged, female, male, low-level light therapy
8 autores
- Joelita de Alencar Fonseca Santos🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- José Erivelton de Souza Maciel Ferreira🇧🇷 · autor de correspondenciaUniversity for International Integration of the Afro-Brazilian Lusophony
- João Wesley da Silva Galvão🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- Ainoã de Oliveira Lima🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- ELAINE CRISTINA SÁ DE ALMEIDA🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- Lukénia André Lukelo🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- Gyrlany Alves Pereira🇧🇷University for International Integration of the Afro-Brazilian Lusophony
- Thiago Moura de Araújo🇧🇷University for International Integration of the Afro-Brazilian Lusophony
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diabetic peripheral neuropathy is a disabling chronic complication of diabetes mellitus, associated with neuropathic pain, sensory dysfunction, and reduced quality of life. Because pharmacological treatments often provide only partial relief, photobiomodulation therapy (PBMT) has emerged as a promising non-pharmacological strategy with metabolic, anti-inflammatory, and neuromodulatory effects. To assess the feasibility of local PBMT, administered alone or combined with intravascular laser irradiation of blood (ILIB), and to explore preliminary short-term changes in neuropathic pain, neuropathic symptoms, and sensory responses in individuals with diabetic peripheral neuropathy. This prospective randomized controlled pilot trial included 26 participants allocated to three groups: local PBMT, local PBMT combined with ILIB, and sham control. All randomized participants completed 12 sessions over 23 days. Neuropathic pain intensity was assessed using the Visual Analog Scale, and neuropathic symptoms were evaluated using the Michigan Neuropathy Screening Instrument. Friedman and McNemar tests were used for exploratory within-group and paired analyses, and a linear mixed-effects model evaluated pain trajectory over time. Neuropathic pain intensity decreased across the five assessment points (p < 0.001), with significant intragroup reduction in the local PBMT group (p = 0.007). Improvements were observed in selected symptoms, including numbness, cramps, and dry skin with fissures. The mixed-effects model showed a significant effect of time on pain reduction (beta = -0.78; p = 0.001), although no significant group x time interaction was detected. Local PBMT, administered alone or combined with ILIB, was feasible in this outpatient pilot trial and was followed by preliminary short-term reductions in neuropathic pain and selected neuropathic symptoms. However, no definitive between-group superiority was demonstrated, and the findings should be interpreted cautiously because of the pilot design, small sample size, heterogeneity in baseline pain intensity, potential placebo effects, and short follow-up period.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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