Differences in Posterior Ocular Morphology Following Red Light Therapy Versus 0.01% Atropine for Myopia Control: A Randomized Controlled Trial Analysis
Zhao Z, Wu Y, Song F, Li M, Wang Y, Chen R, Liu Y, Li J, He M, Chen Y
Investigative ophthalmology & visual science · 0 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-14 · Invest Ophthalmol Vis Sci · vol. 67 · número 8 · pág. 35
- Editorial
- Cadmus Press
- Citado
- 0 citas · más que el 63% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Palabras clave
- Randomized controlled trial, Atropine, Confidence interval, Retinal, Optical coherence tomography
- MeSH
- macula lutea, humans, myopia, atropine, mydriatics, ophthalmic solutions, tomography, optical coherence, adolescent, child, female, male, red light
10 autores
- Ziwei Zhao🇭🇰Hong Kong Polytechnic University
- Yue Wu🇭🇰Hong Kong Polytechnic University
- Fan Song🇭🇰Hong Kong Polytechnic University
- Mingge Li🇨🇳Shenzhen Sixth People's Hospital; ShenZhen People’s Hospital
- Yueye Wang🇭🇰Hong Kong Polytechnic University
- Ruoyu Chen🇭🇰Hong Kong Polytechnic University
- Yanjun Liu🇭🇰Hong Kong Polytechnic University
- Jinying Li🇨🇳Peking University Shenzhen Hospital
- Mingguang He🇭🇰Hong Kong Polytechnic University
- Yanxian Chen🇭🇰 · autor de correspondenciaHong Kong Polytechnic University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this study was to compare longitudinal changes in three-dimensional (3D) macular morphology between repeated low-level red-light (RLRL) therapy and 0.01% low-dose atropine (LDA) treatment in myopic children.
Methods
This secondary analysis of a randomized controlled trial (RCT) included 50 myopic children (aged 7-15 years) randomized to receive either RLRL therapy (650 ± 10 nm) or 0.01% atropine eye drops. Spectral-domain optical coherence tomography (OCT) was performed at baseline and 1, 3, 6, and 12 months. Custom software was used to perform distortion correction and quantify macular curvature (MC; mm-1), macular outward scleral height (MOSH; µm), and their respective asymmetry indices. Primary outcomes were 12-month changes in average regional macular curvature. Secondary outcomes included changes in MOSH, asymmetry indices, and retinal layer thicknesses. Linear mixed-effects models analyzed longitudinal changes.
Results
At 12 months, RLRL showed greater macular flattening than 0.01% atropine across all regions (mean differences, × 10-3 mm-1): central (9.0, 95% confidence interval [CI] = 4.4-13.6, P < 0.01), temporal (9.7, 95% CI = 6.7-12.8, P < 0.001), inferior (8.4, 95% CI = 5.2-11.6, P < 0.001), superior (7.0, 95% CI = 4.0-9.9, P < 0.001), and nasal (3.7, 95% CI = 0.8-6.7, P < 0.05). The inter-group difference was most pronounced centrally and decreased with eccentricity. MOSH decreased superiorly and increased inferiorly in the RLRL group at 12 months, whereas the LDA group showed minimal change. Both nasal-temporal and superior-inferior macular curvature asymmetry indices increased significantly more in the RLRL group (P < 0.001 and P < 0.05, respectively). No inter-group differences in retinal layer thickness changes were observed.
Conclusions
Over 12 months, RLRL showed broader macular flattening and more region-specific MOSH changes compared with 0.01% atropine in this cohort. However, the underlying mechanisms and the independent contribution of myopic progression to these morphological differences require further study.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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