Financiado en parte por AstraZeneca
Examining the feasibility and preliminary effects of resistance exercise training and creatine supplementation in individuals treated for colorectal cancer
Fairman CM, Brooks AM, Candow DG, Jackson KE, Bottone G, Scott B, Anderson KS, Hirsch KR, Cardaci TD, VanderVeen BN, Blake CE, Zhang T, Zhang J, Murphy EA
PloS one · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- AstraZeneca
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of General Medical Sciences
- Gobierno
- NCI NIH HHS
- Gobierno
- NIGMS NIH HHS
- Subvenciones
- National Institute of General Medical Sciences (P20GM155896)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-15 · PLoS One · vol. 21 · número 7 · pág. e0353630
- Editorial
- Public Library of Science
- Citado
- 0 citas · más que el 51% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 91 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cancer survivorship and care · Nutrition and Health in Aging · Muscle metabolism and nutrition
- Palabras clave
- resistance training, creatine supplementation, colorectal cancer survivors, virtual exercise, feasibility, acceptability, safety, muscle strength, physical function, body composition, recruitment and retention
- MeSH
- humans, colorectal neoplasms, creatine, treatment outcome, feasibility studies, body composition, dietary supplements, aged, middle aged, female, male, muscle strength, resistance training
14 autores
- Ciaran M. Fairman🇺🇸 · autor de correspondenciaUniversity of South Carolina
- Alexander M. Brooks🇺🇸University of South Carolina
- Darren G Candow🇨🇦University of Regina
- Kylah E. Jackson🇺🇸University of South Carolina
- Genevieve Bottone🇺🇸University of South Carolina
- Brett Scott🇺🇸University of South Carolina
- Kenneth S. Anderson🇺🇸University of South Carolina
- Katie R. Hirsch🇺🇸University of South Carolina
- Thomas D. Cardaci🇺🇸University of South Carolina; University of Colorado Cancer Center; University of Colorado Anschutz; University of Colorado Denver; Colorado State University
- Brandon N. VanderVeen🇺🇸Wake Forest University
- Christine E. Blake🇺🇸University of South Carolina
- Tiejun Zhang🇺🇸University of South Carolina
- Jiajia Zhang🇺🇸University of South Carolina
- E. Angela Murphy🇺🇸University of South Carolina
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of this trial was to assess the feasibility, acceptability and safety of a 10-week hybrid (in-clinic and virtual) resistance exercise training RET program with or without CrM in individuals treated for colorectal cancer.
Methods
Twenty-seven participants were randomized to RET plus 5 grams/day of CrM (EXSUPP; n = 13) or 5 grams/day corn-starch maltodextrin placebo (EXPLA; n = 14). RET was performed three times per week. Feasibility was assessed through recruitment, retention and fidelity (percentage of prescribed RET and supplementation completed). Acceptability was evaluated using a 5-point Likert scale, and safety was monitored through adverse event reporting. Secondary outcomes (body composition, muscular strength, physical function) were assessed pre- and post-intervention using baseline-adjusted ANCOVA models and focus group interviews.
Results
Registry-based recruitment identified 1378 potentially eligible individuals and 27 of 410 assessed (6.6%) enrolled, highlighting recruitment challenges. Retention was high (24/27; 88.9%). Adherence to RET and supplementation was strong (both > 85%) with no serious adverse events reported. Participants reported high acceptability for both in person and virtual components. No significant between group differences were observed for secondary outcomes; however, both groups demonstrated modest improvements in muscular strength and short physical performance battery (SPPB) scores.
Conclusions
A hybrid RET program with CrM was feasible, acceptable and well tolerated in individuals with colorectal cancer who were previously treated with chemotherapy.
Implications for cancer survivors
Hybrid supervised RET is safe, acceptable, and associated with modest improvements in strength and physical function among individuals treated for colorectal cancer. While creatine supplementation did not demonstrate clear additive effects in this pilot trial, further adequately powered studies are warranted. Trial Registration: NCT06420726.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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