A randomized trial of omega-3 fatty acids plus inositol versus N-acetylcysteine for the treatment of depression and mania in emotionally dysregulated youth age 5-17 with and without autism traits
Wozniak J, Iorini M, DiSalvo M, O'Connor H, Uchida M, Kandel H, Ceranoglu AT, O'Connor M, Faraone S, Joshi G
Journal of affective disorders · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Demarest Lloyd Jr Foundation
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-07-16 · J Affect Disord · vol. 414 · pág. 122277
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 55% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Bipolar Disorder and Treatment · Fatty Acid Research and Health · Treatment of Major Depression
- Palabras clave
- omega-3 fatty acids, myo-inositol, N-acetylcysteine, depression, mania, emotional dysregulation, autistic traits, children and adolescents, nutraceuticals, EPA, bipolar disorder, mood disorders
- MeSH
- humans, inositol, fatty acids, omega-3, acetylcysteine, treatment outcome, drug therapy, combination, affective symptoms, depression, autistic disorder, bipolar disorder, psychiatric status rating scales, dietary supplements, adolescent, child, child, preschool, female, male, mania
10 autores
- Janet R. Wozniak🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital
- Maria Iorini🇺🇸Massachusetts General Hospital
- Maura DiSalvo🇺🇸Massachusetts General Hospital
- Hannah O’Connor🇺🇸Massachusetts General Hospital
- Mai Uchida🇺🇸Harvard University; Massachusetts General Hospital
- Hagar Kandel🇺🇸Harvard University; Massachusetts General Hospital
- Atilla T. Ceranoglu🇺🇸Harvard University; Massachusetts General Hospital
- Meredith O’Connor🇺🇸Massachusetts General Hospital
- Stephen V. Faraone🇺🇸SUNY Upstate Medical University
- Gagan Joshi🇺🇸Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to assess the effectiveness of the nutraceutical treatments combined omega-3 fatty acid plus inositol (O3I) versus N-acetylcysteine (NAC) in children and adolescents with emotional dysregulation and the impact of the co-occurrence of autism traits (AT). Participants were male and female children (5-17) with emotional dysregulation and the presence/absence of AT, as defined by Child Behavior Checklist score, randomized to receive open-label O3I (1020 mg EPA and 1000-2000 mg Inositol) or NAC (1800-2700 mg) daily for 6 weeks. Clinicians measured severity and improvement of depression and mania with the NIMH Clinical Global Improvement Scale (CGI). Parents completed Parent-Youth Mania Rating Scale (P-YMRS) and Children's Depression Inventory (CDI). Both O3I and NAC resulted in modest improvements in mania and depression and did not differ significantly in between group comparison in their effectiveness. Participants taking O3I, but not NAC, demonstrated statistically significant within group improvement in depression per CDI. Participants taking NAC had a greater decrease in P-YMRS scores versus O3I, but the difference did not reach statistical significance. In the presence of AT, NAC was more effective than O3I for mania but not for depression. Further, participants taking NAC, but not O3I, demonstrated significant within group improvement in SRS and BRIEF scores. These results suggest that O3I and NAC may be beneficial for mania and depression in youth, with trends towards O3I more effective for depression and NAC more effective for mania. The presence of AT in youth with emotional dysregulation may moderate the impact of NAC.
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