Comparative efficacy and safety of photobiomodulation, transcranial direct current stimulation, and repetitive transcranial magnetic stimulation in Alzheimer's disease: a network meta-analysis of randomized controlled trials
Xu W, Chen J, Zhou Y, Liu C, Han Y, Zheng K
Lasers in medical science · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Tongji University
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Fundamental Research Funds for the Central Universities
- Subvenciones
- Fundamental Research Funds for the Central Universities (2019kfyXKJC055); National Natural Science Foundation of China (82371442)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-23 · Lasers Med Sci · vol. 41 · número 1
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 38% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Transcranial Magnetic Stimulation Studies · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Palabras clave
- Alzheimer's disease, low-level laser therapy, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, non-invasive brain stimulation, cognitive performance, treatment efficacy, treatment safety, feasibility, comparative effectiveness
- MeSH
- humans, alzheimer disease, treatment outcome, bayes theorem, cognition, transcranial magnetic stimulation, randomized controlled trials as topic, transcranial direct current stimulation, low-level light therapy, cognitive enhancement
6 autores
- Wei Xu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Jiajie Chen🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Yingying Zhou🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Chengzhi Liu🇨🇳Huazhong University of Science and Technology
- Yuelin Han🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Kai Zheng🇨🇳 · autor de correspondenciaTongji Hospital; Huazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which current pharmacological therapies provide only modest and transient benefits, underscoring the need for effective non-pharmacological interventions. Non-invasive brain stimulation (NIBS), including photobiomodulation (PBM), transcranial direct current stimulation (tDCS), and repetitive transcranial magnetic stimulation (rTMS), is a promising approach. This study compared the efficacy, feasibility, and safety of PBM, tDCS, and rTMS in AD. We conducted a Bayesian network meta-analysis (NMA) of randomized controlled trials (RCTs), prospectively registered in PROSPERO (CRD420251006868) and reported according to PRISMA-NMA. The primary outcome was global cognitive performance, assessed by the Mini-Mental State Examination (MMSE) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog). Secondary outcomes were feasibility and safety, evaluated by dropout rates and adverse events, respectively. A total of 34 studies, comprising 35 RCTs (n = 1,559), were included, with one study contributing two independent randomized controlled trials. All three interventions improved global cognitive performance compared with control. PBM showed the highest estimated effects on both MMSE (MD = 3.14, 95% CrI: 1.71 to 4.60) and ADAS-Cog (MD = - 8.01, 95% CrI: -12.82 to - 3.13). In indirect comparisons, PBM was superior to rTMS for ADAS-Cog (MD = - 5.24, 95% CrI: -10.23 to - 0.12), while the MMSE comparison narrowly missed statistical significance (MD = 1.57, 95% CrI: -0.02 to 3.18). These findings were generally consistent across subgroups stratified by baseline cognition and intervention duration. PBM tended to rank highest for cognitive improvement with feasibility and safety comparable to tDCS and rTMS in AD. These findings support the therapeutic potential of PBM, and large-scale RCTs are needed to guide individualized treatment strategies, with implications for clinical decision-making in geriatric care.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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