The impact of vitamin D supplementation on depression and anxiety in young individuals with depression and vitamin D insufficiency/deficiency
Lee YT, Huang HC, Ko KT, Sun FJ, Lee TH, Liu HC, Wu SI, Huang CR, Sung MR, Liu SI
European journal of nutrition · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Science and Technology, Taiwan
- Universidad u hospital
- Mackay Memorial Hospital
- Gobierno
- Ministry of Science and Technology (MOST), Taiwan
- Subvenciones
- Ministry of Science and Technology, Taiwan (MOST109-2314-B195-017-MY3); Mackay Memorial Hospital (MMH-110-17, MMH-111-20, and MMH-112-17)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-07-23 · Eur J Nutr · vol. 65 · número 5
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 56% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Treatment of Major Depression · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, vitamin D deficiency, vitamin D insufficiency, major depressive disorder, anxiety, adolescents, young adults, vitamin D3, depressive symptoms, hypercalcemia, hyperphosphatemia, patient preferences, generalized anxiety disorder, Hamilton Depression Rating Scale, Beck Depression Inventory-II, GAD-7, outpatients
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamin d, depression, anxiety, psychiatric status rating scales, dietary supplements, adolescent, child, female, male, young adult, major depressive disorder
10 autores
- Yun-Tse Lee🇹🇼Mackay Memorial Hospital
- Hui‐Chun Huang🇹🇼Mackay Memorial Hospital
- Kai‐Ting Ko🇹🇼Mackay Memorial Hospital
- Sun Fj🇹🇼Mackay Memorial Hospital
- Tsung-Han Lee🇹🇼Mackay Memorial Hospital
- Hui‐Ching Liu🇹🇼Mackay Memorial Hospital
- Shu‐I Wu🇹🇼Mackay Memorial Hospital; Mackay Medical University
- Chiu-Rong Huang🇹🇼Mackay Memorial Hospital
- Ming-Ru Sung🇹🇼Mackay Memorial Hospital
- Shen‐Ing Liu🇹🇼 · autor de correspondenciaMackay Memorial Hospital; Mackay Medical University; Mackay Junior College of Medicine, Nursing and Management
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study evaluates the effects of vitamin D supplementation on depression and anxiety in young people with major depression and vitamin D insufficiency/deficiency.
Methods
This partially randomized patient preference trial enrolled outpatients aged 10-24 with major depression and vitamin D insufficiency/deficiency. Participants who expressed a preference received vitamin D, while others were randomly assigned to vitamin D or placebo groups. Randomization was performed using computer-generated random numbers in blocks of four, with allocation concealed from researchers, participants, and treating physicians. Supplementation groups received 4,800 IU of vitamin D3 daily for 8 weeks. The primary outcome was assessor-rated depressive symptoms measured using the 17-item Hamilton Depression Rating Scale. Secondary outcomes were self-reported depression (Beck Depression Inventory-II) and anxiety (Generalized Anxiety Disorder-7).
Results
A total of 108 participants were included and assigned to three groups: randomized vitamin D (RVD, n = 41; mild/moderate-to-severe depression, 23/18), preference vitamin D (PVD, n = 28; 16/12), and placebo (PL, n = 39; 23/16). Among adolescents (10-19 years), 9/8 in the RVD group had mild/moderate-to-severe depression, compared to 9/8 in the PVD group, and 10/7 in the PL group. There was no significant difference in depression between the RVD and PL groups (B = - 0.30, 95% CI [- 1.81, 1.21], p = 0.698), however anxiety was reduced in the RVD group (B = - 1.78, 95% CI [- 3.35, - 0.32], p = 0.026). Subgroup analyses revealed that the participants with moderate-to-severe depression in the RVD groups had reduced depression and anxiety versus placebo. However, the subgroup of adolescents with moderate-to-severe depression did not differ in all outcome scores in the RVD versus placebo. There were no significant differences between the PVD and RVD groups. No differences in hypercalcemia or hyperphosphatemia were observed. The trial was completed.
Conclusion
Vitamin D supplementation may benefit young people with moderate-to-severe depression and vitamin D insufficiency/deficiency. While sample size constraints favor an exploratory interpretation of these findings, this study provides a valuable piece of the puzzle; future trials are essential to complete the clinical picture.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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