Impact of Omega-3 Fatty Acid Docosahexaenoic Acid Supplementation in Individuals During Pregnancy on Neurodevelopment and Growth of Offspring: Systematic Review and Meta-Analysis
Xie L, Zhou M, Lu L, Ning X, Song Y
Developmental psychobiology · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Open Fund of Development and Regeneration Key Laboratory of Sichuan Province
- Gobierno
- Joint Innovation Fund Project of Chengdu Municipal Health Commission and Universities
Según 2 financiadores declarados.
Publicación
- Publicado
- 2026-07-01 · Dev Psychobiol · vol. 68 · número 4 · pág. e70184
- Editorial
- Wiley
- Citado
- 0 citas · más que el 48% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Child Nutrition and Water Access
- Palabras clave
- docosahexaenoic acid, omega-3 fatty acids, prenatal supplementation, maternal nutrition, offspring neurodevelopment, birth weight, head circumference, gestational age, birth length, fetal brain development, retinal development, executive function, short-term memory
- MeSH
- humans, birth weight, docosahexaenoic acids, child development, pregnancy, dietary supplements, female, neurodevelopment
5 autores
- Linyun Xie🇨🇳Chengdu Medical College
- Meicen Zhou🇨🇳Sichuan University; West China Second University Hospital of Sichuan University
- Liqun Lu🇨🇳First Affiliated Hospital of Chengdu Medical College
- XueMei Ning🇨🇳First Affiliated Hospital of Chengdu Medical College
- Yue Song🇨🇳First Affiliated Hospital of Chengdu Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Maternal prenatal docosahexaenoic acid (DHA) intake is critical for fetal brain and retinal development; however, evidence regarding its effects on offspring neurodevelopment and growth remains inconsistent. This systematic review and meta-analysis evaluated the efficacy of prenatal DHA supplementation on offspring neurodevelopmental outcomes (attention, motor, intelligence, language, executive function, and short-term memory) and growth parameters (birth weight, head circumference, gestational age, and birth length) in the general population. We analyzed randomized controlled trials (RCTs) from 2001 to 2023 across PubMed, Embase, and the Cochrane Library. Of 917 records, 21 RCTs were included in the systematic review, of which 19 were eligible for meta-analysis. The meta-analysis showed that prenatal DHA supplementation had no significant benefits on any neurodevelopmental outcome. Subgroup analyses revealed no improvements across all assessed domains (all p > 0.05). In contrast, prenatal DHA supplementation significantly increased neonatal birth weight (mean difference [MD] = 72.51 g, 95% CI: 37.55-107.48), whereas no notable improvements were observed in head circumference, gestational age, birth length, or any of the assessed neurodevelopmental outcomes. Overall, the current evidence does not support benefits of prenatal DHA supplementation for neurodevelopmental outcomes or for growth outcomes other than birth weight in the general population. Future research should focus on identifying subgroups that may be responsive to DHA based on genetic, nutritional, or environmental factors.
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