The effect of simultaneous application of plant-rich ketogenic diet and intermittent fasting on early-to-mid-stage Alzheimer's disease: a randomised controlled trial
Tağraf B, Kaygusuz D, Yerlikaya D, Oğul ÖE, Hanoğlu L
The journal of nutrition, health & aging · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-24 · J Nutr Health Aging · vol. 30 · número 9 · pág. 100930
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 56% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Diet and metabolism studies · Dementia and Cognitive Impairment Research · Dietary Effects on Health
- Palabras clave
- Alzheimer's disease, intermittent fasting, cognitive function, cognitive decline, dietary intervention, brain structure, metabolic phenotypes
- MeSH
- humans, alzheimer disease, treatment outcome, fasting, cognition, aged, aged, 80 and over, middle aged, female, male, mental status and dementia tests, diet, ketogenic, intermittent fasting
5 autores
- Beyza Tağraf🇹🇷 · autor de correspondenciaIstanbul Medipol University
- Dilara Kaygusuz🇹🇷Istanbul Medipol University
- Deniz Yerlikaya🇹🇷Dokuz Eylül University
- Özden Erkan Oğul🇹🇷Istanbul Medipol University
- Lütfü Hanoğlu🇹🇷Istanbul Medipol University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
This study evaluates the effect of simultaneous application of plant-rich ketogenic diet and intermittent fasting as an individualized adjunct to standard treatment on cognitive function in early/mid-stage Alzheimer's patients.
Methods
This assessor-blinded, randomized controlled trial enrolled 60 Alzheimer's disease (AD) patients (CDR 1-2; aged 55-85), randomized to intervention (n = 30; intervention + standard care) or control (n = 30; standard care). Cognition and brain structure were assessed at baseline and 6 months. Individual cognitive changes were analyzed using Reliable Change Index (RCI).
Results
Cognitive change scores differed significantly between groups (p < 0.001). The mean Mini Mental State Examination (MMSE) score increased by +0.9 in the intervention group, while a decrease of -1.5 points was observed in the control group. RCI analysis indicated stability in 93% of intervention and 70% of control participants, with cognitive improvement in 7% and 3.3%, respectively.
Discussion
The intervention method has the potential to stabilize cognitive decline in AD and promote improvement at the individual level. The response to the intervention is closely related to the individual's metabolic phenotype and structural brain integrity.
Ethical approval
Istanbul Medipol University Non-Interventional Clinical Research Ethics Committee on March 6, 2025, under number 242 and the study was carried out in accordance with the Declaration of Helsinki and its later amendments.
Clinicaltrials
gov ID: NCT06898424.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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