Effect of vitamin D supplementation on clinical outcomes of patients with Parkinson disease: A randomized controlled study
Anamnart C, Kitjarak R
Medicine · 0 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-07-24 · Medicine (Baltimore) · vol. 105 · número 30 · pág. e49931
- Editorial
- Wolters Kluwer
- Citado
- 0 citas · más que el 56% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Parkinson's Disease Mechanisms and Treatments · Neurological disorders and treatments
- Palabras clave
- Parkinson's disease, vitamin D supplementation, vitamin D deficiency, vitamin D3, 25-hydroxyvitamin D, motor function, cognitive function, quality of life, Thai patients, tropical climate
- MeSH
- humans, parkinson disease, vitamin d deficiency, cholecalciferol, vitamin d, treatment outcome, prevalence, dietary supplements, aged, middle aged, thailand, female, male
2 autores
- Chumpol Anamnart🇹🇭Prapokklao Hospital
- Ram Kitjarak🇹🇭Prapokklao Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency is linked to Parkinson disease (PD) pathogenesis; however, clinical trial results remain inconclusive. Thus, in this study, we aimed to evaluate the prevalence of vitamin D deficiency in Thai patients with PD and the efficacy of vitamin D3 supplementation on clinical outcomes in a tropical, sun-abundant region.
Methods
In this randomized controlled trial, we enrolled 60 patients with PD and 60 healthy controls. Patients with PD were randomized 1:1 to receive 2000 IU/d of vitamin D3 or no additional treatment (control) for 12 weeks. Primary outcomes included changes in MDS-UPDRS, Hoehn and Yahr (mH&Y), Thai Mini-Mental State Examination, and PDQ-39 scores. The secondary outcome was the prevalence of vitamin D deficiency (25(OH)D < 20 ng/mL).
Results
At baseline, vitamin D deficiency was significantly more prevalent in patients with PD than in healthy controls (23.2% vs 10.0%, P = .046). After 12 weeks, the vitamin D group showed a significant increase in serum 25(OH)D levels compared to the control group (P < .001, successfully normalizing levels in the deficiency subgroup (30.96 ± 3.18 ng/mL). Although Thai Mini-Mental State Examination scores improved significantly within the vitamin D group (mean difference 1.37, P < .001), a similar improvement occurred in the control group (mean difference 0.93, P = .010), with no significant difference between groups (P = .378). No significant improvements were observed in motor function (MDS-UPDRS, mH&Y) or quality of life (PDQ-39).
Conclusion
Vitamin D deficiency is common among Thai patients with PD, despite equatorial proximity. While 2000 IU/d of vitamin D3 safely corrected nutritional deficiency, it provided no significant short-term motor or cognitive benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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