Time-Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study
Duan D, Carnell S, Pilla SJ, Chung ST, Clark JM, Maruthur NM
Obesity (Silver Spring, Md.) · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Universidad u hospital
- Johns Hopkins University
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Gobierno
- NIDDK NIH HHS
- Gobierno
- National Institutes of Health (NIH)
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK126825); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK139324); American Heart Association (17SFRN33590069); National Institute of Diabetes and Digestive and Kidney Diseases (R03DK144349)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-27 · Obesity (Silver Spring) · vol. 34 · número 9 · págs. 1732–1741
- Editorial
- Wiley
- Citado
- 0 citas · más que el 57% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Dietary Effects on Health · Regulation of Appetite and Obesity · Eating Disorders and Behaviors
- Palabras clave
- time-restricted eating, prediabetes, type 2 diabetes, dietary habits, appetite-regulating hormones, ghrelin, leptin, adiponectin, C-reactive protein, cortisol, soluble receptor for advanced glycation end products, inflammation, weight loss, hunger, disinhibition, restraint
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, obesity, inflammation, weight loss, hydrocortisone, leptin, c-reactive protein, body mass index, fasting, feeding behavior, hunger, appetite, adult, aged, middle aged, female, male, adiponectin, ghrelin, surveys and questionnaires, intermittent fasting
6 autores
- Daisy Duan🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine
- Susan Carnell🇺🇸Johns Hopkins University
- Scott J. Pilla🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Stephanie Therese Chung🇺🇸National Institute of Diabetes and Digestive and Kidney Diseases
- Jeanne M. Clark🇺🇸Rutgers, The State University of New Jersey
- Nisa M. Maruthur🇺🇸University of Maryland, Baltimore; Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Time-restricted eating (TRE) has gained attention for weight loss and cardiometabolic health improvement. The Time-Restricted Intake of Meals (TRIM) study was a 12-week randomized isocaloric and eucaloric feeding trial comparing 10-h TRE to a 16-h usual eating pattern (UEP) in adults with obesity and either prediabetes or diet-controlled type 2 diabetes. This post hoc analysis investigates TRE's effects on eating behavior, appetite hormones, and inflammatory markers.
Methods
Participants completed the Three-Factor Eating Questionnaire (Restraint, Disinhibition, Hunger) and provided fasting blood samples for leptin, adiponectin, CRP, cortisol, and sRAGE at pre- and post-intervention. Ghrelin was measured during a 75 g OGTT. Wilcoxon signed rank and Mann-Whitney U tests were used for within- and between-group differences.
Results
Thirty-nine participants (19 TRE; 20 UEP) were analyzed, with a mean (SD) age of 60 (7) years and BMI of 35.2 (6.0) kg/m2. Weight loss was similar across groups (2.7% TRE; 2.5% UEP). Both arms increased restraint and decreased disinhibition and hunger. No statistically significant between-group differences were observed in eating behavior, appetite hormones, and inflammatory markers.
Conclusions
Both 10-h TRE and 16-h UEP promoted improvements in eating behavior in the context of modest and equivalent weight loss. Larger prospective studies are needed to confirm whether clinically meaningful differences exist.
Trial registration
ClinicalTrials.gov NCT03527368.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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