Short-Term Effect of a Wild Blueberry (<i>Vaccinium angustifolium</i>) Drink on Vascular Reactivity and Circulating Adhesion Molecules in Healthy Adults: A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial
Rendine M, Venturi S, Marino M, Martini D, Riso P, Battezzati A, Klimis-Zacas D, Del Bo' C
Nutrients · 0 citas
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Publicación
- Publicado
- 2026-07-21 · Nutrients · vol. 18 · número 14 · pág. 2376
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 51% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- Vaccinium angustifolium, anthocyanins, chlorogenic acid, polyphenols, vascular reactivity, microvascular reactivity, reactive hyperemia index, arterial stiffness, augmentation index, adhesion molecules, VCAM-1, E-selectin, CD15, blood pressure, healthy young adults
- MeSH
- humans, anthocyanins, cell adhesion molecules, e-selectin, vascular cell adhesion molecule-1, cross-over studies, double-blind method, blood pressure, heart rate, adult, female, male, young adult, vascular stiffness, biomarkers, fruit and vegetable juices, blueberry plants
8 autores
- Marco Rendine🇮🇹University of Milan
- Samuele Venturi🇮🇹University of Milan
- Mirko Marino🇮🇹University of Milan
- Daniela Martini🇮🇹University of Milan
- Patrizia Riso🇮🇹University of Milan
- Alberto Battezzati🇮🇹University of Milan
- Dorothy J. Klimis‐Zacas🇺🇸University of Maine
- Cristian Del Bo’🇮🇹 · autor de correspondenciaUniversity of Milan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Wild blueberries (WB), abundant in (poly)phenols such as anthocyanins and chlorogenic acids, have shown vascular benefits in several preclinical and epidemiological settings. However, evidence from human trials remains limited. This double-blind, randomized, placebo-controlled, crossover trial investigated the effects of the consumption of a WB drink on vascular reactivity and circulating adhesion molecules in healthy young adults. Methods: Participants received 300 mL of a WB drink (30 g of freeze-dried WB powder containing 740 mg total (poly)phenols, 460 mg total anthocyanins and 170 mg chlorogenic acid) or the same amount of a placebo (PL) drink. Blood pressure, heart rate, microvascular reactivity (i.e., reactive hyperemia index, RHI, lnRHI and FRHI) and arterial stiffness (i.e., augmentation index, AIx) were assessed at baseline and 2 h after consumption of the WB and PL drinks using Endo-PAT2000. In addition, plasma circulating adhesion molecules including vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and cluster of differentiation 15 (CD 15 or Lewis x) were analyzed using ELISA. Results: Overall, analysis of variance did not show a significant effect of treatment on the modulation of markers of vascular function and adhesion molecules but revealed an effect of time, with an increase in terms of microvascular reactivity (RHI, p p p p p Conclusions: In conclusion, the intake of a WB drink failed to affect vascular function in young healthy subjects. Larger-scale and longer-term intervention studies, particularly in individuals at increased cardiovascular risk and in those with vascular dysfunction, are warranted to further explore the role of WB in modulating vascular reactivity.
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