Effect of Phototherapy on Calcium, Magnesium, and Vitamin D Levels in Neonates with Hyperbilirubinemia: A Systematic Review and Meta-Analysis
Molatefi R, Mirzarahimi M, Mirghafourvand M, Vazifeh A
Current pediatric reviews · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-07-23 · Curr Pediatr Rev · vol. 22
- Editorial
- Bentham Science Publishers
- Citado
- 1 cita · más que el 98% de estudios similares · 9.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Neonatal Health and Biochemistry · Vitamin D Research Studies · Pediatric Hepatobiliary Diseases and Treatments
- Palabras clave
- phototherapy, neonatal hyperbilirubinemia, serum calcium, hypocalcemia, serum magnesium, hypomagnesemia, vitamin D, term infants, phototherapy adverse effects, electrolyte imbalance, neonatal jaundice treatment, GRADE, quality of evidence, effect size heterogeneity
4 autores
- Rasol Molatefi🇮🇷Ardabil University of Medical Sciences
- Mehrdad Mirzarahimi🇮🇷Ardabil University of Medical Sciences
- Mojgan Mirghafourvand🇮🇷Tabriz University of Medical Sciences
- Abdollah Vazifeh🇮🇷 · autor de correspondenciaArdabil University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
This study aimed to evaluate the impact of phototherapy on serum calcium, magnesium, and vitamin D levels in term neonates.
Methods
This study was conducted in accordance with the PRISMA statement. A comprehensive search of PubMed, Scopus, Web of Science, the Cochrane Library, and the Scientific Information Database (SID) was performed up to August 20, 2025. Pooled effect sizes were calculated as Hedges' g and mean differences (MD) with 95% Confidence Intervals (CIs) using random-effects models. Heterogeneity was assessed using the I2 statistic. Study quality was appraised using the Newcastle- Ottawa Scale, ROBINS-I, and RoB 2 tools, and the certainty of evidence was evaluated per GRADE methodology.
Results
Twenty-seven studies were included. Phototherapy was associated with a significant decrease in serum calcium (Hedges' g = -0.67; 95% CI: -0.89 to -0.45; MD: -0.57 mg/dL; 95% CI: - 0.75 to -0.40; 22 studies; 2,406 participants) and magnesium levels (Hedges' g = -1.09; 95% CI: - 1.54 to -0.63; MD: -0.21 mg/dL; 95% CI: -0.33 to -0.10; 10 studies; 863 participants), with considerable heterogeneity observed for both outcomes. Vitamin D levels showed a non-significant overall increase (Hedges' g = 0.40; 95% CI: -0.06 to 0.87; MD: 5.86 nmol/L; 95% CI: -2.06 to 13.77; 7 studies; 517 participants; p = 0.091). The pooled prevalence of hypocalcemia and hypomagnesemia following phototherapy was 26.1% (95% CI: 20.8% to 32.3%) and 23.8% (95% CI: 18.6% to 30.0%), respectively. The certainty of evidence was rated as low for calcium and magnesium, and very low for vitamin D.
Discussion
This meta-analysis indicates that phototherapy in term neonates is associated with significant decreases in serum calcium and magnesium, while its effect on vitamin D remains inconclusive. These findings highlight the need for monitoring electrolyte balance in at-risk neonates, although routine supplementation is not currently supported by the evidence.
Conclusion
Phototherapy is associated with a significant decrease in calcium and magnesium levels in term neonates. Given the low certainty of evidence, high-quality randomized controlled trials with standardized protocols are warranted to guide clinical practice. PROSPERO registration number: CRD42025638904.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.