Potential Role of Omega-3 Supplementation in Modulating Symptoms and Holter Parameters in Pediatric Inappropriate Sinus Tachycardia
El-Baz MA, El Wan SAS, Mohamed RS, Gouda EK, El-Tabakh YMKA, Rahman EGA
Indian journal of pediatrics · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-07-28 · Indian J Pediatr · vol. 93 · número 10 · págs. 1040–1045
- Editorial
- Springer Science+Business Media
- Citado
- 1 cita · más que el 96% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 18 trabajos
- Acceso
- De pago
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Fatty Acid Research and Health · Cardiac electrophysiology and arrhythmias
- Palabras clave
- omega-3 fatty acids, inappropriate sinus tachycardia, pediatric arrhythmia, heart rate variability, rate control, Holter monitoring, obesity, prehypertension, treatment response, anxiety
- MeSH
- humans, tachycardia, sinus, fatty acids, omega-3, electrocardiography, ambulatory, treatment outcome, prospective studies, heart rate, dietary supplements, adolescent, child, female, male
6 autores
- Mohamed A. EL- Baz🇪🇬Benha University
- Somaia A. Elwan🇪🇬Benha University
- Rodina Sobhy Mohamed🇪🇬Benha University
- Eman Khaled Gouda🇪🇬Benha University
- Yousra M. El -Tabakh🇪🇬 · autor de correspondenciaCairo University
- Eman G. Abdel Rahman🇪🇬Benha University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To evaluate the effect of omega-3 supplementation on heart rate (HR) control and heart rate variability (HRV) in children with inappropriate sinus tachycardia (IST).
Methods
This prospective randomized controlled trial included 60 children (aged 12-16 y) diagnosed with IST. Participants were randomized into two groups: Group A received omega-3 supplementation for 3 mo, while Group B received standard follow-up without treatment. Baseline and post-treatment HR, HRV parameters [Standard deviation of NN intervals (SDNN), Root mean square of successive differences (RMSSD), pNN50], and clinical outcomes were assessed using 24-h Holter monitoring and validated scales.
Results
After 3 mo, the omega-3 group showed significant reductions in maximum HR (from 160.5 ± 17.9 to 142.2 ± 15.7 bpm, p = 0.000) and average HR (from 98.9 ± 4.7 to 90.7 ± 5.5 bpm, p = 0.000). HRV indices also improved significantly: SDNN (p = 0.000), RMSD (p = 0.000), and pNN50 (p = 0.000). In contrast, no significant changes were observed in the control group. Clinical improvement was significantly higher in the omega-3 group (63.3% marked improvement) compared to controls (p <0.001). Obesity (p = 0.049) and pre-hypertension (p <0.001) were associated with poor response to omega-3 therapy. No significant differences in anxiety scores were found between groups.
Conclusions
Omega-3 supplementation significantly improved HR control and HRV in pediatric IST patients. Obesity and elevated blood pressure may limit treatment efficacy.
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