Early-life high-dose omega-3 polyunsaturated fatty acid supplementation reduces risk of childhood asthma/wheezing: A meta-analysis of randomized controlled trials
Cai S, Ji X, He Y, Zhou Y, Ge S, Gu M, Shang Y, Wang S, Yu D, Ren S, Zhou D, Zhang X
Asia Pacific journal of clinical nutrition · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ningbo Municipal Public Welfare Research Plan
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Municipal Key R&D Program of Ningbo
- Gobierno
- Ningbo Natural Science Foundation
- Organización sin fines de lucro
- K. C. Wong Magna Fund in Ningbo
Según 5 financiadores declarados.
Publicación
- Publicado
- 2026-08-01 · Asia Pac J Clin Nutr · vol. 35 · número 4 · págs. 623–630
- Editorial
- National Institutes of Health
- Citado
- 0 citas · más que el 51% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Vitamin D Research Studies
- Palabras clave
- omega-3 polyunsaturated fatty acids, childhood asthma, wheezing, eicosapentaenoic acid, high-dose supplementation, dose-response relationship, asthma prevention, anti-inflammatory therapy
- MeSH
- humans, asthma, respiratory sounds, fatty acids, omega-3, dose-response relationship, drug, dietary supplements, child, child, preschool, infant, randomized controlled trials as topic
12 autores
- Sisi Cai🇨🇳Ningbo University
- Xinyue Ji🇨🇳Ningbo University
- Yang He🇨🇳Ningbo University
- Ying Zhou🇨🇳Ningbo University; Ningbo Medical Center Lihuili Hospital
- Sangwangjiu Ge🇨🇳Ningbo University
- Mengting Gu🇨🇳Ningbo University
- Yujia Shang🇨🇳Ningbo University
- Shihan Wang🇨🇳Ningbo University
- Danyue Yu🇨🇳Ningbo University
- Simeng Ren🇨🇳Wenzhou-Kean University
- Dezheng Zhou🇨🇳Ningbo University; Ningbo Medical Center Lihuili Hospital
- Xiaohong Zhang🇨🇳Ningbo University; Ningbo Medical Center Lihuili Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Asthma, a chronic inflammatory airway disease characterized by wheezing, imposes a substantial global health burden on children. Given the potential of early-life omega-3 polyunsaturated fatty acid (omega-3 PUFA) supplementation as an anti-inflammatory intervention to prevent childhood asthma and wheezing, this meta-analysis aims to clarify its efficacy and investigate dose-dependency.
Methods and study design
This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Three reviewers independently evaluated the studies, extracted data, and assessed bias using the Jadad scale. The outcomes included the risk of asthma/wheezing: pooled odds ratios (ORs) were calculated using fixed-effects models, along with sensitivity/subgroup analyses and dose-response meta-regression.
Results
Twelve randomized controlled trials (RCTs) involving 4,156 participants showed no overall association between omega-3 PUFA and a reduced risk of asthma/wheezing (odds ratio [OR]: 1.00; 95% confidence interval [CI]: 0.84-1.18). However, high-dose supplementation (≥1,200 mg/day) significantly decreased the risk (OR: 0.66; 95% CI: 0.46-0.94). Similarly, high-dose eicosapentaenoic acid (EPA≥1,000 mg/day) also significantly reduced the risk (OR: 0.67; 95% CI: 0.46-0.97). Dose-response analysis confirmed a linear relationship (p=0.002), indicating a 26.6% reduction in risk for every 1,000 mg/day increase in dose (OR: 0.734; 95% CI: 0.602-0.896). Subgroup analyses revealed no heterogeneity with respect to study location, allergy risk, or follow-up duration.
Conclusions
Early-life omega-3 PUFA supplementation reduces childhood asthma/wheezing risk in a dose-dependent manner. High-dose regimens, particularly those involving EPA, provide substantial protection, suggesting a potential clinical strategy for prevention, although further validation is required.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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