Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials
Abumweis S, Alqadi S, Al Tarteer A, Alrefai W, Alzoughool F, Jew S, Qudah T
Asia Pacific journal of clinical nutrition · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Hashemite University (Jordan)
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-08-01 · Asia Pac J Clin Nutr · vol. 35 · número 4 · págs. 631–643
- Editorial
- National Institutes of Health
- Citado
- 0 citas · más que el 53% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health Studies · Nutritional Studies and Diet
- Palabras clave
- vitamin D supplementation, cardiovascular risk factors, LDL cholesterol, systolic blood pressure, fasting blood glucose, HbA1c, age differences, cardiometabolic risk
- MeSH
- humans, cardiovascular diseases, blood glucose, vitamin d, risk factors, blood pressure, dietary supplements, randomized controlled trials as topic, heart disease risk factors, cardiometabolic risk factors
7 autores
- Suhad Abumweis🇯🇴Hashemite University
- Sarah Alqadi
- Ala’a Al Tarteer
- Waed Alrefai🇦🇺Swinburne University of Technology
- Foad Alzoughool🇦🇪🇯🇴Higher Colleges of Technology; Hashemite University
- Stephanie Jew
- Taima Qudah🇦🇪Al Ain University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Vitamin D has been proposed to influence several cardiometabolic risk factors; however, evidence from randomized controlled trials (RCTs) and recent meta-analyses remains inconsistent regarding the magnitude of these effects. This meta-analysis evaluated the effects of vitamin D supplementation on lipid profile, blood pressure, and glycaemic parameters, and explored whether age and baseline serum vitamin D concentrations modified these associations.
Methods and study design
A systematic review and meta-analysis of RCTs was conducted to compare oral vitamin D supplementation with placebo in adults. PubMed, the Cochrane Library, and ClinicalTrials.gov were searched systematically. Risk of bias was as-sessed using the Cochrane risk-of-bias tool. Pooled effect sizes with 95% confidence intervals (CIs) were estimated using random-effects models.
Results
A total of 14,051 abstracts were identified, and 45 RCTs were included in the final analysis. Vitamin D supplementation significantly reduced low-density lipoprotein cho-lesterol (LDL-C) by 0.136 mmol/L (95% CI: -0.215, -0.056), systolic blood pressure (SBP) by 2.79 mm Hg (95% CI: -4.65, -0.94), fasting blood glucose (FBG) by 0.11 mmol/L (95% CI: -0.19, -0.04), and hemoglobin A1c (HbA1c) by 0.164% (95% CI: -0.32, -0.01) compared with placebo. Subgroup analyses showed reductions in SBP and LDL-C among participants aged ≥55 years, whereas FBG was reduced in those aged <55 years. While favorable effects on FBG and HbA1c were observed with a baseline blood level of vitamin D of less than 50 nmol/L.
Conclusions
Vitamin D supplementation may modestly improve selected cardiomet-abolic risk factors. Age and baseline vitamin D status may influence these effects, although their clinical sig-nificance remains uncertain. Further well-designed RCTs are needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.