The effect of oral magnesium supplementation on glycemic control and metabolic parameters in type 2 diabetes mellitus: a double-blind randomized controlled trial
Al-Maqbali JS, Al Alawi AM, Osman A, Al-Farqani A, Kumar S, Al Futisi A, Al-Mamari A, Al-Zakwani I, Al Za'abi M
Frontiers in endocrinology · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-07-16 · Front Endocrinol (Lausanne) · vol. 17 · pág. 1883483
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 60% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Palabras clave
- Glycated hemoglobin, Hypomagnesemia, Randomized controlled trial, Glycemic, Type 2 diabetes, Diabetes mellitus, Placebo, Type 2 Diabetes Mellitus, Adverse effect
- MeSH
- humans, diabetes mellitus, type 2, magnesium, magnesium oxide, blood glucose, administration, oral, prospective studies, double-blind method, dietary supplements, aged, middle aged, female, male, biomarkers, glycemic control, glycated hemoglobin
9 autores
- Juhaina Salim Al-Maqbali🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital; Sultan Qaboos University
- Abdullah M. Al Alawi🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital
- Alaa Osman🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital
- Ahmed Al-Farqani🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital
- Suneel Kumar🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital
- Abdullah Al Futisi🇴🇲Sultan Qaboos University
- Ali Al-Mamari🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital
- Ibrahim Al-Zakwani🇴🇲Sultan Qaboos Hospital; Sultan Qaboos University Hospital; Sultan Qaboos University
- Mohammed Al Za’abi🇴🇲Sultan Qaboos University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
This randomized controlled trial (RCT) assessed the effect of oral magnesium (Mg) supplementation on glycated hemoglobin (HbA1c) and metabolic biomarkers in adults with Type 2 Diabetes Mellitus (T2DM).
Methods
This was a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial with intention-to-treat (ITT) and per-protocol (PP) analyses. Adults (≥18 years) with T2DM were randomized 1:1 to receive magnesium oxide (500 mg; 302 mg elemental) or placebo. Eligibility criteria included a glycated hemoglobin (HbA1c) level ≥7.0% and a creatinine clearance >30 mL/min. Simple randomization was performed using a sealed-envelope method. Biochemical and clinical parameters were assessed at baseline and at three follow-up visits over 12 months.
Results
A total of 247 participants were included in the ITT analysis (Mg-oxide, n=118; placebo, n=129). Median age was 58 (50-65) years, and median diabetes duration was 16 (10-22) years. Hypomagnesemia was present in 7.3% by ionized magnesium (iMg) and 8.1% by total magnesium (tMg). Mg-oxide supplementation significantly reduced fasting blood glucose in a subgroup of the cohort (FBG; p = 0.039) and resulted in a modest, non-significant reduction in HbA1c (-0.30% vs. -0.05%; p = 0.145), with a higher proportion achieving goal attainment/controlled HbA1c (p = 0.043). HbA1c reductions were more pronounced among participants with baseline hypomagnesemia (-0.60% vs. +0.25%; p = 0.074), or diabetes duration ≤15 years (-0.40% vs. 0.00%; p = 0.085). No differences were observed in other metabolic parameters, clinical outcomes or adverse drug reactions between groups.
Conclusions
Although median HbA1c reduction did not reach statistical significance, Mg-oxide supplementation improved Mg status and showed favorable trends in glycemic control without compromising safety. These findings support Mg supplementation as a safe adjunct to long-term T2DM management, particularly among selected subgroups, given the study's limitations.
Clinical ttrial registration
https://clinicaltrials.gov/, identifier NCTO5774015.
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