Effects of vitamin D supplementation on insulin resistance and lipid metabolic profiles in women with gestational diabetes mellitus: A randomized controlled trial
Duan Y, Zhang S, Ma X, Li L, Jia K
African journal of reproductive health · 0 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Publicación
- Publicado
- 2026-07-31 · Afr J Reprod Health · vol. 30 · número 14 · págs. 86–93
- Editorial
- African Journals OnLine
- Citado
- 0 citas · más que el 59% de estudios similares · 0.0× el promedio de su campo
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- Acceso
- Acceso abierto (publicación gratuita)
- Áreas de investigación
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- gestational diabetes mellitus, vitamin D supplementation, vitamin D3, insulin resistance, lipid metabolism, 25-hydroxyvitamin D, glycemic control, triglycerides, LDL cholesterol, HDL cholesterol, maternal metabolic health, pregnancy
- MeSH
- humans, diabetes, gestational, insulin resistance, vitamin d deficiency, insulin, blood glucose, lipids, vitamins, vitamin d, double-blind method, pregnancy, dietary supplements, adult, female, lipid metabolism
5 autores
- Yunhui Duan🇨🇳Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University
- Shixuan Zhang🇨🇳Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University
- Xiaojun Ma🇨🇳Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University
- Li Li🇨🇳Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University
- Kai Jia🇨🇳Capital Medical University; Beijing Chao-Yang Hospital, Capital Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Gestational diabetes mellitus (GDM) commonly presents as insulin resistance and altered lipid metabolism, with evidence linking vitamin D deficiency to its pathogenesis. In this randomized, double-blind, placebo-controlled trial, 120 pregnant women diagnosed with GDM were assigned to receive either vitamin D3 supplements (2000 IU/day) or a placebo for 3 months. Serum vitamin D status, glycemic control parameters, and lipid profiles were evaluated pre- and post-intervention, adjusting for dietary and exercise confounders. After the 3-month intervention, serum 25-hydroxyvitamin D levels in the vitamin D group were significantly higher than those in the placebo group. Vitamin D supplementation effectively reduced fasting plasma glucose, fasting insulin, and HOMA-IR scores. Simultaneously, it significantly decreased triglycerides and LDL-C levels while increasing HDL-C. Total cholesterol levels showed no statistically significant difference between the two groups. Supplementation with 2000 IU vitamin D per day for 3 months yields significant improvements in glucose homeostasis and lipid metabolism in the GDM population. Vitamin D holds promise as an effective auxiliary treatment to enhance maternal metabolic health.
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