Vitamin D Deficiency During Pregnancy Is Associated With Greater LDL-C Increase, Elevated β-Hydroxybutyrate and Altered Neonatal Metabolic Markers-A Secondary, Pooled Analysis of the Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)
Harreiter J, Gisinger T, Mendoza LC, Simmons D, Desoye G, Devlieger R, Galjaard S, Damm P, Mathiesen ER, Jensen DM, Andersen LLT, Dunne F, Lapolla A, Dalfra MG, Bertolotto A, Wender-Ozegowska E, Zawiejska A, Hill D, Jelsma JGM, Snoek FJ, Worda C, Bancher-Todesca D, van Poppel MNM, Corcoy R, Kautzky-Willer A
Endocrinology, diabetes & metabolism · 0 citas
Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- ZonMw
- Universidad u hospital
- KU Leuven
- Organización sin fines de lucro
- Sociedad Española de Diabetes
- Gobierno
- European Community's 7th Framework Programme (FP7/2007-2013)
- Gobierno
- Medical Scientific Fund of the Mayor of Vienna
- Gobierno
- Polish Ministry of Science
- Universidad u hospital
- Odense University Free Research Fund
- Organización sin fines de lucro
- Spanish Diabetes Society (SED) XI Grant
- Gobierno
- NIHR Clinical Research Network
- Sin clasificar
- CAIBER
- Subvenciones
- National Institute for Health and Care Research (FP7/2007–2013); ZonMw (1527-B-226); ZonMw (242187); ZonMw (200310013)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-13 · Endocrinol Diabetes Metab · vol. 9 · número 5 · pág. e70258
- Editorial
- Bioscientifica
- Citado
- 0 citas · más que el 62% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Birth, Development, and Health
- Palabras clave
- vitamin D deficiency, pregnancy, LDL cholesterol, beta-hydroxybutyrate, ketone bodies, umbilical cord blood, maternal obesity, maternal overweight, lipid metabolism, ketogenesis
- MeSH
- fetal blood, humans, pregnancy complications, diabetes, gestational, vitamin d deficiency, 3-hydroxybutyric acid, vitamin d, pregnancy, adult, infant, newborn, female, cholesterol, ldl, biomarkers
25 autores
- Jürgen Harreiter🇦🇹 · autor de correspondenciaMedical University of Vienna
- Teresa Gisinger🇦🇹Medical University of Vienna
- Lilian Cristina Mendoza🇪🇸Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- David S Simmons🇦🇺Western Sydney University
- Gernot Desoyé🇦🇹Medical University of Graz
- Roland Devlieger🇧🇪Universitair Ziekenhuis Leuven; GZA Ziekenhuizen Campus Sint-Augustinus; GZA Ziekenhuizen; KU Leuven
- Sander Galjaard🇧🇪🇳🇱Universitair Ziekenhuis Leuven; Erasmus MC; KU Leuven
- Peter Damm🇩🇰University of Copenhagen; Rigshospitalet
- Elisabeth Reinhardt Mathiesen🇩🇰University of Copenhagen; Rigshospitalet
- Dorte M. Jensen🇩🇰University of Southern Denmark; Odense University Hospital
- Lise Lotte T. Andersen🇩🇰University of Southern Denmark; Odense University Hospital
- Fidelma Dunne🇮🇪Ollscoil na Gaillimhe – University of Galway
- Annunziata Lapolla🇮🇹University of Padua
- Maria Grazia Dalfrà🇮🇹University of Padua
- Alessandra Bertolotto🇮🇹Azienda Ospedaliera Universitaria Pisana
- Ewa Wender-Ożegowska🇵🇱Poznan University of Medical Sciences
- Agnieszka Zawiejska🇵🇱Poznan University of Medical Sciences
- David J. Hill🇨🇦Lawson Health Research Institute
- Judith G. M. Jelsma🇳🇱Amsterdam Public Health; Amsterdam University Medical Centers; Vrije Universiteit Amsterdam
- Frank Jan Snoek🇳🇱Amsterdam Public Health; Amsterdam University Medical Centers; Vrije Universiteit Amsterdam
- Christof Worda🇦🇹Medical University of Vienna
- Dagmar Bancher‐Todesca🇦🇹Medical University of Vienna
- Mireille N. M. van Poppel🇦🇹🇳🇱University of Graz; Amsterdam Public Health; Amsterdam University Medical Centers; Vrije Universiteit Amsterdam
- Rosa Corcoy🇪🇸Universitat Autònoma de Barcelona; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- Alexandra Kautzky‐Willer🇦🇹Medical University of Vienna
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Vitamin D (vitD) plays a role in metabolic regulation, including lipid metabolism and insulin sensitivity. During pregnancy, profound physiological changes in lipid handling and ketogenesis occur to support fetal development. However, the extent to which maternal vitamin D status influences these metabolic adaptations and fetal metabolic markers remains unclear.
Methods
In this secondary analysis, we examined lipid distribution throughout pregnancy-from before 20 weeks' gestation to delivery-in women with overweight or obesity, stratified by vitamin D status (deficiency, insufficiency, or sufficiency), assessing both maternal and cord blood. Main inclusion criteria were: age > =18 years, singleton pregnancy, 2. Women with GDM 50 nmol/L, n = 638) groups. VitD levels and lipid concentrations were assessed at < 20, 24-28 and 35-37 weeks' gestation and in cord blood.
Results
Compared with vitD sufficient women, women with vitD deficiency had significantly larger increases in LDL-C throughout pregnancy and ß-OH-butyrate at 24-28 weeks' gestation, in adjusted analysis. VitD in cord blood was highest in offspring of mothers with vitD sufficiency. In cord blood, significantly higher ß-OH-butyrate was observed with vitD deficiency; lipid concentrations were similar between groups.
Conclusions
Early vitamin D deficiency before 20 weeks of gestation was associated with altered metabolic trajectories during pregnancy, including greater increases in LDL cholesterol and ketone body concentrations in women with overweight or obesity, as well as higher cord blood ketone levels in their offspring. These findings suggest that early maternal vitamin D status may influence maternal and fetal metabolic adaptations, although causal relationships and clinical implications require further investigation.
Trial registration
Trial registered at ISRCTN registry (https://doi.org/10.1186/ISRCTN70595832) trial number ISRCTN70595832. Registration date 02/12/2011.
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