Dose dependent effects of transcranial photobiomodulation on blood-oxygenation-level-dependent power in major depressive disorder
Iosifescu DV, Collins KA, Tural U, Dmochowski JP, Gaggi N, Parincu Z, Peterson A, Hurtado-Puerto AM, Gersten MB, Clancy JA, McEachern KM, Sobeih T, de Taboada L, Tarpey T, Cassano P
Brain stimulation · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIA NIH HHS
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (R61 /R33 MH122647)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-08-13 · Brain Stimul · vol. 19 · número 5 · pág. 103185
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 95% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Transcranial Magnetic Stimulation Studies · Treatment of Major Depression
- Palabras clave
- transcranial photobiomodulation, major depressive disorder, dose-dependent effects, BOLD signal, hemodynamic response, prefrontal cortex, middle frontal gyrus, near-infrared light, antidepressant effects, pulsatile stimulation, sham control
- MeSH
- brain, prefrontal cortex, humans, oxygen, magnetic resonance imaging, dose-response relationship, radiation, adult, middle aged, female, male, young adult, low-level light therapy, major depressive disorder
15 autores
- Dan Vlad Iosifescu🇺🇸 · autor de correspondenciaNathan Kline Institute for Psychiatric Research; New York University
- Katherine A. Collins🇺🇸Nathan Kline Institute for Psychiatric Research
- Ümit Tural🇺🇸Nathan Kline Institute for Psychiatric Research
- Jacek Dmochowski🇺🇸City University of New York
- Naomi Love Gaggi🇺🇸Nathan Kline Institute for Psychiatric Research; New York University
- Zamfira Parincu🇺🇸Nathan Kline Institute for Psychiatric Research; New York University
- Anna Peterson🇺🇸New York University
- Aura Maria Hurtado Puerto🇺🇸Massachusetts General Hospital
- Maia Beth Gersten🇺🇸Massachusetts General Hospital
- Julie A. Clancy🇺🇸Massachusetts General Hospital
- Kayla Marie McEachern🇺🇸Massachusetts General Hospital
- Tarek M. Sobeih🇺🇸Nathan Kline Institute for Psychiatric Research
- Luis de Taboada
- Thaddeus Tarpey🇺🇸New York University
- Paolo Cassano🇺🇸Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Transcranial photobiomodulation (t-PBM) with near-infrared light stimulates mitochondria and may have antidepressant effects. We evaluated dose-dependent effects of t-PBM on the hemodynamic blood-oxygenation-level-dependent (BOLD) power in major depressive disorder (MDD).
Methods
31 MDD subjects underwent randomly assigned t-PBM sessions, 1/week, in the MRI scanner, with 1) Sham; 2) High dose: pulse wave, irradiance ∼300 mW/cm2; 3) Medium dose: continuous wave, ∼300 mW/cm2; and 4) Low dose: continuous wave, ∼50 mW/cm2 t-PBM (808 nm) was delivered to the prefrontal cortex, bilaterally. fMRI was recorded at 3T before, during, and after t-PBM. We used mixed-effects linear regression to evaluate changes in BOLD power during stimulation, compared to sham. The analysis was repeated for the middle frontal gyrus (MFG), the prefrontal areas irradiated by t-PBM, and the entire brain cortex.
Results
We found similar results in the MFG, the prefrontal cortex directly irradiated, and the entire brain cortex: medium dose t-PBM was associated with a statistically significant increase in BOLD power, whereas low dose t-PBM was associated with a significant decrease in BOLD. There were no significant changes in BOLD power with the high (pulsed) t-PBM dose or with sham. Single administrations of any t-PBM dose did not result in significant changes in depression severity (versus sham). All 3 t-PBM doses were well tolerated.
Conclusion
The acute effect of t-PBM on the hemodynamic BOLD power is robust, dose-dependent, bidirectional, and extends beyond the areas directly illuminated. These findings may provide a reference for future dose selection and clinical efficacy studies.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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