Comparison of effects between daily repeated low-level red light therapy and 0.01% low-dose atropine for myopia prevention: A propensity score matching study
Ma X, Zhao Y, Zhou Y, Sun H, Liu S, Yin W
Photodiagnosis and photodynamic therapy · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-08-20 · Photodiagnosis Photodyn Ther · vol. 61 · pág. 105624
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 77% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Palabras clave
- Propensity score matching, Incidence (geometry), Mean difference, Prospective cohort study, Significant difference, Atropine, Red light
6 autores
- Xiaoqian Ma
- Yang Zhao🇨🇳China National Pharmaceutical Group Corporation (China)
- Yuanpei Zhou
- Hongyan Sun
- 刘苏冰 · autor de correspondencia
- Weijing Yin · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To compare the preventive effect of daily repeated low-level red light (RLRL) and 0.01% low-dose atropine eye drops (LDA) on myopia.
Methods
This was a 12-month prospective comparative study. 216 Children aged 7-12 years using either RLRL or LDA for myopia prevention were enrolled between July 10, 2024 to August 15, 2024. 192 completed the 12-month follow-up, last case went for clinical visit on August 28, 2025. The primary outcome was the 12-month myopia incidence. Secondary outcomes included changes in the spherical equivalent error (SER) and changes in the axial length (AL).
Results
The 12-month myopia incidence was 30.7% (36/117) and 13.3% (10/75) for the LDA and RLRL groups, respectively. The former was significantly higher than the latter (difference, 17.4%, 95% CI: 5.2% to 28.1%; p = 0.028). 69 pairs of children were matched from each group using propensity matching score method, where age, gender, baseline SER, and baseline AL were balanced between groups. The 12-month myopia incidence was 29.0% (20/69) and 11.6% (8/69) for the LDA and RLRL groups, respectively. The LDA group was still significantly higher than the RLRL group (difference, 17.4%, 95% CI: 3.9% to 30.3%; p = 0.038). The 12-month changes in the SER were 0.08 D and -0.49 D for the RLRL group and the LDA group, respectively, the mean difference was -0.57 (95% CI:-0.73 to -0.41) D, p < 0.001. The average changes in AL were 0.02 mm and 0.29 mm for the RLRL group and LDA group, respectively, the mean difference was 0.27 (95% CI: 0.11 to 0.43) mm, p < 0.001. 19.7% (23/117) Children in the LDA group reported photophobia, no adverse event was observed in the RLRL group.
Conclusion and relevance
In this 12-month study, daily RLRL demonstrated superior myopia prevention compared to 0.01% LDA. Myopia incidence was significantly lower with RLRL, with a 60% reduced risk. Propensity-matched analysis confirmed RLRL's efficacy, which better stabilized refractive status and axial elongation. No adverse events occurred with RLRL, while 19.7% of LDA users reported photophobia. RLRL emerges as a safer, more effective preventive intervention for childhood myopia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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