Early, midday, and late time-restricted eating impact on anthropometry and cardiometabolic health: a network meta-analysis of RCTs
Hamsho M, Shkorfu W, Terzi M, Ranneh Y, Varady KA, Fadel A
Frontiers in nutrition · 2 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-06 · Front Nutr · vol. 13 · pág. 1887087
- Editorial
- Frontiers Media
- Citado
- 2 citas · más que el 96% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 78 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Palabras clave
- Anthropometry, Meal, Randomized controlled trial, Calorie, Meta-analysis
6 autores
- Mohammed Hamsho🇹🇷Istanbul Yeni Yüzyıl University
- Wijdan Shkorfu🇹🇷Bahçeşehir University
- Merve Terzi🇹🇷Istanbul Yeni Yüzyıl University
- Yazan Ranneh🇦🇪🇺🇸Al Ain University; Academy of Nutrition and Dietetics
- Krista A Varady🇺🇸University of Illinois Chicago
- Abdulmannan Fadel🇦🇪 · autor de correspondenciaUnited Arab Emirates University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This network meta-analysis (NMA) evaluates the physiological effects of early time-restricted eating (eTRE), midday TRE (mTRE), and late TRE (lTRE), with and without exercise (EX), calorie restriction (CR), and control on anthropometric and metabolic indices in adults with cardiometabolic risk factors.
Methods
A comprehensive literature search was conducted in PubMed, Web of Science, Scopus, and Embase up to April 24, 2025. A Bayesian NMA was performed. Treatment effects were expressed as mean differences (MD) with 95% credible intervals (CrI). Intervention rankings were assessed using the surface under the cumulative ranking curve (SUCRA). Certainty of evidence was evaluated using the GRADE approach.
Results
Thirty-nine randomized controlled trials including 3,236 participants were analyzed. Most interventions, except mTRE + EX, reduced anthropometric measures compared with control. eTRE reduced fasting blood glucose (MD -3.64 mg/dL, 95% CrI -5.93 to -1.36) and HOMA-IR (MD -0.42, 95% CrI -0.83 to -0.03), compared with control group. eTRE + EX reduced HOMA-IR (MD -1.33, 95% CrI -2.58 to -0.08). Across outcomes, eTRE + EX and eTRE consistently ranked highest according to SUCRA. Certainty of evidence ranged from very low to moderate for most anthropometric and metabolic outcomes.
Conclusion
Although clear differences between TRE patterns and CR were limited, consistent SUCRA rankings favored eTRE, particularly when combined with exercise, which may suggest a potential role of meal timing in metabolic regulation. However, these rankings should be interpreted cautiously, as they were based on a limited number of trials, and the certainty of evidence ranged from very low to moderate for most outcomes.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD420251018349.
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