A pilot study of daily blueberry intake modulates the gut microbiota enzyme commissions in older, sedentary adults with mild depressive symptoms
Millar CL, Chopra MP, Morgan X, Green EA, Wolfe A, Pierce KA, Gao L, Blesso CN, Dufour AB, Kiel DP, Lipsitz LA
The journal of nutrition, health & aging · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Massachusetts Institute of Technology
- Universidad u hospital
- Harvard University
- Universidad u hospital
- Broad Institute
- Gobierno
- National Institute of Food and Agriculture
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute on Aging (P30AG048785); National Institute of Food and Agriculture (2023-67017-39055)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-21 · J Nutr Health Aging · vol. 30 · número 10 · pág. 100958
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 57% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Gut microbiota and health · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Palabras clave
- gut microbiota, depressive symptoms, older adults, sedentary adults, GABA, short-chain fatty acids, anthocyanins, dietary fiber, mood
- MeSH
- feces, humans, fruit, fatty acids, volatile, pilot projects, double-blind method, depression, aged, female, male, gastrointestinal microbiome, blueberry plants, sedentary behavior
11 autores
- Courtney L. Millar🇺🇸 · autor de correspondenciaBeth Israel Deaconess Medical Center; Harvard University; Hebrew SeniorLife
- Mohit P. Chopra🇺🇸Beth Israel Deaconess Medical Center; Harvard University; Hebrew SeniorLife
- Xochitl C. Morgan🇺🇸Harvard University
- Emily Anne Green🇺🇸Harvard University
- Alex Wolfe🇺🇸Hebrew SeniorLife
- Kerry A. Pierce🇺🇸Broad Institute; Harvard University; Massachusetts Institute of Technology
- Lidan Gao🇺🇸University of Connecticut
- Christopher N. Blesso🇺🇸University of Connecticut
- Alyssa B. Dufour🇺🇸Beth Israel Deaconess Medical Center; Harvard University; Hebrew SeniorLife
- Douglas P. Kiel🇺🇸Beth Israel Deaconess Medical Center; Harvard University; Hebrew SeniorLife
- Lewis Arnold Lipsitz🇺🇸Beth Israel Deaconess Medical Center; Harvard University; Hebrew SeniorLife
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Fiber and anthocyanins in blueberries have potential to modify the gut microbiome and metabolites that are relevant to depression in older adults.
Objective
Our objective was to preliminarily determine the effect of blueberry consumption on the gut microbiome, metabolites, and depressive symptoms.
Design
Sedentary, older adults (≥65y) with mild depressive symptoms were enrolled in a randomized, double-blind, parallel-arm, placebo-controlled pilot study. Participants consumed 48 g/day of blueberry powder (∼2 cups of fresh berries) or placebo for 3 months. Metagenomic sequencing measured the abundance of fecal bacterial species and genes, liquid chromatography/mass spectrometry evaluated gut-derived fecal short chain fatty acids (SCFA), and validated questionnaires evaluated depressive symptoms before and after the intervention.
Participants
Eighteen participants who were predominantly female and white completed the intervention (Placebo Group, n = 8, mean age: 75 ± 6; Blueberry Group, n = 10, mean age: 71 ± 4).
Results
Measures of species abundance, MetaCyc pathways, and metabolites did not change. There were statistically significant in the gene abundance of several Enzyme Commissions (EC) of the gut microbiome within the Blueberry Group-including EC 3.6.3.31 Polyamine Transporting ATPase, which is involved in the production of the neurotransmitter, gamma-aminobutyric acid (GABA).
Conclusion
While there were no statistically significant differences in changes in depressive symptoms between groups, the magnitude of reduction in depressive symptom severity appeared greater, with smaller variability in the Blueberry Group, which was paired with minor changes in the gut microbial ECs. Our data are preliminary and warrant additional studies to investigate the link between blueberries, the gut-microbiome, and mood in older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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