Acute dietary nitrate supplementation attenuates caffeine-induced increase in arterial stiffness in healthy adults: a randomized cross-over trial
McLellan AG, Ahmad NSB, Acton JP, Punni HK, O'Donnell E, Shepherd AI, Perissiou M, James LJ, Clifford T, Bailey SJ
Food & function · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Loughborough University
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-01-01 · Food Funct · vol. 17 · número 18 · págs. 8145–8157
- Editorial
- Royal Society of Chemistry
- Citado
- 0 citas · más que el 68% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Coffee research and impacts · Nitric Oxide and Endothelin Effects
- Palabras clave
- dietary nitrate, beetroot, caffeine, arterial stiffness, acute supplementation, healthy adults
- MeSH
- humans, beta vulgaris, nitrates, caffeine, cross-over studies, double-blind method, blood pressure, dietary supplements, adult, female, male, young adult, vascular stiffness
10 autores
- Abbie Grace McLellan🇬🇧Loughborough University; University of Oxford
- Nur S B Ahmad🇲🇾🇬🇧Universiti Sains Malaysia; Loughborough University
- Jarred P. Acton🇬🇧Loughborough University; Loughborough College
- Harjot K Punni🇬🇧Loughborough University
- Emma O'Donnell🇬🇧Loughborough University
- Anthony I. Shepherd🇬🇧University of Portsmouth
- Maria Perissiou🇬🇧University of Portsmouth
- Lewis John James🇬🇧Loughborough University
- Tom Clifford🇬🇧Loughborough University
- Stephen J. Bailey🇬🇧Loughborough University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose: Inorganic nitrate (NO3-) supplementation and caffeine have been shown to have conflicting effects on various aspects of cardiovascular function. This study evaluated whether NO3- supplementation would attenuate caffeine-induced cardiovascular strain. Methods: Twenty-four (17 males; age: 24(3) years) healthy participants completed four trials in a randomized, double-blind, placebo-controlled crossover design. The trials were nitrate (NO3-)-rich (400 mg NO3-) and NO3--depleted (92 mg NO3-) beetroot powder consumed, with (BR-CAF and CAF) and without (BR and PL) 6 mg kg-1 caffeine. Brachial and central blood pressure (BP) and arterial stiffness variables were measured pre- and post-supplementation (2.5 h). Macrovascular endothelial function was assessed post-supplementation using flow mediated dilation (FMD). Results: Arterial stiffness measures of augmentation pressure (mmHg) and index (%) were higher following CAF (+3(2) mmHg and 10(9)%) than PL (+1(3) mmHg and +4(11)%) and BR (+0(3) mmHg and +1(11)%; P P = 0.505-0.689). Brachial BP, central BP and macrovascular endothelial function were not altered with BR or CAF compared to PL (P = 0.067-0.359). Plasma [nitrite] was higher in BR and BR-CAF than PL and CAF (P P = 0.370). Conclusion: Acute NO3- supplementation offset caffeine-induced increases in arterial stiffness variables. These findings improve our understanding of the cardiovascular health benefits afforded by acute NO3- consumption under cardiovascular strain.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.