A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome
Gosalia J, Spicuzza JM, Bowlus C, Brinkerhoff A, Baker SR, Qiu JJ, Kim-Shapiro DB, Pawelczyk JA, Proctor DN
Physiological reports · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
- Organización sin fines de lucro
- Huck Family Endowment for Nutritional Research in Family Medicine at Penn State College of Medicine and University Park
- Subvenciones
- National Center for Advancing Translational Sciences (UL 1 TR002014)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-01 · Physiol Rep · vol. 14 · número 16 · pág. e71073
- Editorial
- Wiley
- Citado
- 0 citas · más que el 70% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects · Cardiovascular and exercise physiology
- Palabras clave
- nitrate supplementation, beetroot juice, dynamic cerebral autoregulation, metabolic syndrome, older adults, nitric oxide bioavailability, cerebrovascular function, cerebral blood flow, cognitive decline, plasma nitrate, transfer function analysis, functional near-infrared spectroscopy
- MeSH
- humans, nitrates, pilot projects, double-blind method, homeostasis, cerebrovascular circulation, dietary supplements, aged, middle aged, female, male, fruit and vegetable juices, metabolic syndrome
9 autores
- Jigar Gosalia🇺🇸University of Colorado Anschutz
- Jocelyn M. Delgado Spicuzza🇺🇸University of Pittsburgh
- Christine K. Bowlus🇺🇸Pennsylvania State University
- Annabelle Brinkerhoff🇺🇸Pennsylvania State University
- Stephen R. Baker🇺🇸Wake Forest University
- Juan Jan Qiu🇺🇸Pennsylvania State University
- Daniel B. Kim‐Shapiro🇺🇸Wake Forest University
- Jim A. Pawelczyk🇺🇸Pennsylvania State University
- David N. Proctor🇺🇸 · autor de correspondenciaPennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Metabolic syndrome (MetS) is associated with reduced nitric oxide (NO) bioavailability and impaired cerebrovascular function, potentially increasing cognitive decline risk. Dynamic cerebral autoregulation (dCA) maintains cerebral blood flow and may involve NO-related vascular mechanisms. Whether dietary nitrate supplementation influences dCA in MetS remains unclear. This pilot trial evaluated feasibility and explored effects of nitrate supplementation on dCA. Twenty-two older adults with MetS (55-75 years) were randomized in a double-blind, placebo-controlled design to receive nitrate-rich beetroot juice (BRJ; 6.4 mmol NO3 -·day-1) or nitrate-depleted placebo for 4 week. dCA was assessed using transfer function analysis (TFA) of beat-to-beat blood pressure and functional near-infrared spectroscopy-derived cerebral oxygenation. Primary analyses examined frontal dCA holistically, with exploratory regional and cognitive outcomes. dCA was indexed by TFA phase and gain. The intervention was well tolerated, adherence was high, and BRJ increased plasma nitrate concentrations versus placebo (p < 0.001). No significant effects were observed for frontal dCA or cognition. Exploratory analyses indicated region-specific differences in dCA in select frontal areas, characterized by improvements in TFA phase and gain. This pilot trial demonstrates the feasibility of dietary nitrate supplementation in MetS. While no effects were observed in primary outcomes, exploratory analyses suggest potential region-specific improvements in dCA.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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