Financiado en parte por U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Supplementations of docosahexaenoic acid and blueberry suppress a high-fat breakfast-induced postprandial inflammation but only docosahexaenoic acid improves endothelial function in healthy adults: a randomized, double-blind, placebo-controlled crossover intervention study
Huang S, Kirschke C, Bosviel R, Mo Z, Bonnel EL, Woodhouse LR, Burnett DJ, Peerson JM, Huang L, Newman JW, Rutledge JC, Hwang DH
Nutrition research (New York, N.Y.) · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institute of Food and Agriculture
- Gobierno
- USDA NIFA
- Gobierno
- US Department of Agriculture
- Grupo de la industria
- US Highbush Blueberry Council
Según 6 financiadores declarados.
Publicación
- Publicado
- 2026-07-18 · Nutr Res · vol. 154 · págs. 12–31
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 51% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet
- Palabras clave
- docosahexaenoic acid, blueberry, omega-3 fatty acids, high-fat meal, postprandial inflammation, endothelial function, IL-1β, cyclooxygenase-2, monocyte activation, reactive hyperemia index, lipoprotein lipase, TC/HDL-C ratio, dietary supplementation, cardiometabolic health, healthy adults
- MeSH
- endothelium, vascular, humans, fruit, inflammation, dietary fats, docosahexaenoic acids, cross-over studies, double-blind method, postprandial period, dietary supplements, adult, female, male, interleukin-1beta, diet, high-fat, breakfast, blueberry plants
12 autores
- Shurong Huang🇺🇸Western Human Nutrition Research Center
- Catherine P. Kirschke🇺🇸Western Human Nutrition Research Center
- Rémy Bosviel🇺🇸University of California, Davis
- Zhenzhen Mo🇺🇸Western Human Nutrition Research Center; University of California, Davis
- Ellen L. Bonnel🇺🇸University of California, Davis
- Leslie R. Woodhouse🇺🇸Western Human Nutrition Research Center
- Dustin J. Burnett🇺🇸Western Human Nutrition Research Center; University of California, Davis
- Janet M Peerson🇺🇸Western Human Nutrition Research Center
- Liping Huang🇺🇸Western Human Nutrition Research Center; University of California, Davis
- John W. Newman🇺🇸United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- John C. Rutledge🇺🇸University of California, Davis
- Daniel H. Hwang🇺🇸 · autor de correspondenciaWestern Human Nutrition Research Center; University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberries and n - 3 polyunsaturated fatty acids each can provide protection against inflammation and cardiometabolic disorders. However, the underlying mechanisms are not fully understood. We hypothesized that blueberry and docosahexaenoic acid (DHA) can suppress high fat (HF) meal-induced postprandial inflammation and improve endothelial function. Sixty-two healthy participants (age: 26.8 ± 1.2 y; BMI: 22.1 ± 1.2 kg/m²) consumed an isoenergetic breakfast (850 kcal) containing 34.7 g mostly animal fat (36% kcal), 25.3 g protein, and 111 g carbohydrate, with or without either 42.2 g blueberry powder (BBP) or 1.76 g DHA in a randomized, double-blind, placebo-controlled crossover intervention study. Blood samples were collected before and 1 h, 3 h and 6 h after breakfast. Monocyte activation, proinflammatory gene expression, cytokine production and endothelial function were assessed. Compared with the placebo control, DHA supplementation suppressed the HF breakfast-induced: expression of IL-1β by 21.6% (P < .01) and prostaglandin-endoperoxide synthase 2 (PTGS2, i.e., cyclooxygenase 2) by 22.8% (P < .01) at 6 h; plasma IL-1β production by 40.1 to 49.8% (P < .01) at 1-6 h; lipoprotein lipase (LPL)-treated blood IL-1β production by 40.9% (P < .0001) at 6 h; and total cholesterol/HDL cholesterol ratio by 2.2% (P < .01) at 3 h and 3.5% (P < .0001) at 6 h. BBP supplementation suppressed LPL-treated blood IL-1β production by 23.1% (P < .05) at 6 h. BBP and DHA also induced postprandial increases in reactive hyperemia index (RHI) scores relative to the fasting baselines, with DHA producing a 13.3% increase compared with placebo at 6 h (P < .05). In conclusion, supplementation with BBP or DHA suppressed the HF meal-induced postprandial inflammation but only DHA improved postprandial endothelial function. This study was registered at clinicaltrails.gov (NCT02472171).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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