Association between vitamin D deficiency and chronic kidney disease progression: A GRADE-based dose-response systematic review and meta-analysis
Mojtahedi SY, Sedighiyan M, Pourpashang P
Medicine · 0 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2026-09-04 · Medicine (Baltimore) · vol. 105 · número 36 · pág. e50522
- Editorial
- Wolters Kluwer
- Citado
- 0 citas · más que el 71% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Chronic Kidney Disease and Diabetes · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D deficiency, chronic kidney disease progression, 25-hydroxyvitamin D, serum vitamin D levels, dose-response relationship, renal function decline, vitamin D supplementation, quality of evidence, follow-up duration, study quality heterogeneity, comorbidities
- MeSH
- humans, vitamin d deficiency, disease progression, vitamin d, odds ratio, renal insufficiency, chronic
3 autores
- Sayed Yousef Mojtahedi🇮🇷Bahrami Hospital; Tehran University of Medical Sciences
- Mohsen Sedighiyan🇮🇷Bahrami Hospital; Tehran University of Medical Sciences
- Paniz Pourpashang🇮🇷Bahrami Hospital; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
This systematic review and dose-response meta-analysis aimed to evaluate the association between serum vitamin D status and chronic kidney disease (CKD) progression.
Methods
We searched PubMed, Scopus, Web of Science, and Embase for relevant observational and cohort studies published between 1990 and 2024. Eligible studies reported baseline vitamin D levels and CKD progression outcomes. We performed a random-effects meta-analysis to calculate the pooled odds ratio (OR) for CKD progression. A dose-response meta-analysis examined the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and risk, while subgroup analyses explored follow-up duration, study quality, and comorbid conditions. We assessed evidence certainty using the Grading of Recommendations Assessment, Development and Evaluation approach.
Results
Eleven studies met the inclusion criteria. The pooled analysis suggested that vitamin D deficiency was associated with 33% higher odds of CKD progression (OR = 1.33, 95% confidence interval [CI]: 1.06-1.67; P = .019); however, between-study heterogeneity was considerable (I-squared heterogeneity statistic [I2] = 98.2%). The pooled estimate should therefore be interpreted cautiously as an average association across heterogeneous studies. A dose-response analysis of 10 studies suggested higher odds of CKD progression per 10 ng/mL lower 25(OH)D concentration (OR = 1.18, 95% CI: 1.09-1.25), although its interpretation was limited by reconstructed category-level exposure values. Subgroup analyses showed stronger associations in studies with long-term follow-up (≥5 years; OR = 2.07, 95% CI: 1.29-3.14; P = .001) and high-quality studies (OR = 1.35, 95% CI: 1.06-1.69; P = .03). The Grading of Recommendations Assessment, Development and Evaluation assessment rated the certainty of evidence as very low for the overall association and low for the dose-response analysis, primarily because of the observational study designs and substantial between-study heterogeneity.
Conclusion
Lower serum 25(OH)D levels were associated with higher odds of CKD progression. However, the observational nature of the evidence does not establish that routine screening or vitamin D supplementation can prevent renal function decline. Prospective studies and randomized trials are needed to clarify the clinical utility of vitamin D assessment and supplementation for renal outcomes.
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