Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis
Yao L, Yang D, Gao J
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-25 · Front Nutr · vol. 13 · pág. 1919884
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 53% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Sports Performance and Training
- Palabras clave
- creatine supplementation, resistance training, older adults, muscle strength, muscle mass, physical function, sarcopenia
3 autores
- Lingzi Yao
- Doudou Yang🇨🇳Guangdong University of Science and Technology
- Jiajia Gao🇨🇳 · autor de correspondenciaTianjin University of Sport
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To systematically evaluate the additional effects of creatine supplementation combined with resistance training, compared with resistance training alone, on muscle strength, muscle mass and physical function in older adults.
Methods
PubMed, Embase, the Cochrane Library and Web of Science were searched from inception to 20 May 2026. Randomized controlled trials enrolling older adults aged 60 years and older and comparing creatine supplementation plus resistance training with resistance training alone or placebo plus resistance training were included. Three-level random-effects meta-analyses were conducted using the metafor package in R, allowing multiple correlated effect sizes from the same study to be retained while accounting for their statistical dependence. Risk of bias was assessed using the ROBUST-RCT tool, and the certainty of evidence was evaluated using the GRADE approach.
Results
Eleven randomized controlled trials were included. Three-level meta-analysis showed that creatine supplementation combined with resistance training significantly improved muscle strength compared with resistance training alone, although the effect size was small (g = 0.31, 95% CI 0.18 to 0.45); the certainty of evidence for this outcome was moderate. The pooled effects on muscle mass (g = 0.35, 95% CI -0.09 to 0.78) and physical function (g = 0.47, 95% CI -0.08 to 1.03; p = 0.086) were not statistically significant, with low and very low certainty of evidence, respectively. Moderator analyses did not identify creatine dose, loading phase, intervention duration, training frequency, training intensity, sex or testing site as stable sources of effect variation. Sensitivity analyses indicated that the main findings were not materially influenced by any single effect size or study.
Conclusion
In generally healthy older adults, creatine supplementation may serve as an adjunct to resistance training for modest improvements in muscle strength. Its additional effects on muscle mass and physical function remain uncertain. These findings should not be directly extrapolated to frail, sarcopenic or functionally limited older adults. Larger, well-reported randomized controlled trials are needed in these higher-risk older adult populations.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/, identifier CRD420261417231.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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