Effects of a Combined Vitamin D<sub>3</sub> and Docosahexaenoic Acid Intervention on Cognitive Function and Blood Pyroptotic Biomarkers in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized, Double-Blind, Placebo-Controlled Trial
Yuan J, Yang R, Chen H, Zhao H, Chen X, Lou Z, Han X, Ma F
Nutrients · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82373573)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-08-25 · Nutrients · vol. 18 · número 17 · pág. 2777
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 68% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dementia and Cognitive Impairment Research · Fatty Acid Research and Health · Vitamin D Research Studies
- Palabras clave
- vitamin D3, docosahexaenoic acid, mild cognitive impairment, older adults, cognitive function, pyroptosis, gasdermin D, NLRP3 inflammasome, caspase-1, IL-1β, IL-18, dietary supplementation, combination supplementation, mediation
- MeSH
- humans, cholecalciferol, docosahexaenoic acids, interleukin-18, double-blind method, cognition, dietary supplements, aged, female, male, interleukin-1beta, biomarkers, nlr family, pyrin domain-containing 3 protein, cognitive dysfunction, cognitive enhancement
8 autores
- Jing Yuan🇨🇳Tianjin Medical University
- Ruifang Yang🇨🇳Tianjin Medical University
- Hui Chen🇨🇳Tianjin Medical University
- Huichao Zhao🇨🇳Tianjin Medical University
- Xuan Chen🇨🇳Tianjin Medical University
- Ziyan Lou🇨🇳Tianjin Medical University
- Xinze Han🇨🇳Tianjin Medical University
- Fei Ma🇨🇳 · autor de correspondenciaTianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: This study aimed to assess the effects of a combined vitamin D3 (VD3) and docosahexaenoic acid (DHA) intervention on cognitive function and blood pyroptotic biomarkers in older adults with mild cognitive impairment (MCI). Methods: In total, 360 participants with MCI were recruited, and randomly assigned into four groups: VD3 (800 IU/day), DHA (1 g/day), VD3+DHA (VD3 800 IU/day+DHA 1 g/day), and placebo. Cognitive function was evaluated by the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC), and blood biomarkers were measured by ELISA and Western blot at baseline, 6 months and 12 months. Linear mixed-effects models (LMMs) were employed to analyze longitudinal interaction effects on cognitive function and blood biomarkers. Structural equation modeling (SEM) was conducted to evaluate the parallel mediation effects of blood biomarkers on cognitive improvements. Results: A total of 355 participants completed the trial. Over the 12-month intervention, all intervention groups demonstrated significant improvements in cognitive function and reductions in five blood biomarkers (IL-1β, IL-18, NLRP3, Gasdermin D (GSDMD), cleaved caspase-1) compared to the placebo group (p 3 and DHA intervention yielded superior cognitive improvements in scores for full-scale IQ (FIQ), performance IQ (PIQ), verbal IQ (VIQ) and several subtests (information, comprehension, digit span, vocabulary, picture completion, block design, and picture arrangement), and significantly reduced five blood pyroptotic biomarkers (all p Conclusions: A 12-month intervention with VD3, DHA, or their combination significantly improves cognitive function and mitigates pyroptosis, and the combined intervention showed superior benefits, potentially mediated by downregulating the protein GSDMD.
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