Impact of a standardised music intervention on serum cortisol among sedated, mechanically ventilated adults in the intensive care unit: A randomised controlled trial
Fernández-Álvarez C, Zuazua-Rico D, Maestro-González A, Mosteiro-Díaz MP
Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Sociedad Española de Enfermería Intensiva y Unidades Coronarias
Según 1 financiador declarado.
Publicación
- Publicado
- 2026-09-19 · Aust Crit Care · vol. 39 · número 5 · pág. 101686
- Editorial
- Elsevier BV
- Citado
- 1 cita · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Music Therapy and Health · Intensive Care Unit Cognitive Disorders · Family and Patient Care in Intensive Care Units
- Palabras clave
- music intervention, serum cortisol, mechanical ventilation, intensive care unit, sedation, critical illness, stress response, non-pharmacological treatment, noise-canceling headphones, physiological stability, hemodynamic stability, critically ill adults, mechanical ventilation duration, physiological biomarkers, physiological stress response, physiological stress
- MeSH
- humans, critical illness, hydrocortisone, music therapy, respiration, artificial, single-blind method, aged, middle aged, intensive care units, spain, female, male
4 autores
- Fernández-Álvarez Carmen🇪🇸Hospital Universitario Central de Asturias
- David Zuazua-Rico🇪🇸Universidad de Oviedo; Hospital Universitario Central de Asturias
- Alba Maestro-González🇪🇸 · autor de correspondenciaUniversidad de Oviedo
- María Pilar Mosteiro Díaz🇪🇸Universidad de Oviedo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Patients receiving invasive mechanical ventilation (IMV) in the intensive care unit (ICU) experience significant physiological stress, which may impair recovery. Music intervention is a promising nonpharmacological strategy to modulate stress responses; however, evidence on its effects on biomarkers such as cortisol remains limited in sedated ICU patients.
Objective
The aim of this study was to evaluate the effect of a standardised music intervention on serum cortisol levels in critically ill adults undergoing IMV.
Methods
A single-blind randomised controlled trial was conducted in a tertiary public hospital in Spain. Sedated patients (bispectral index: 40-60) on IMV were randomised to either an intervention group (n = 55) receiving a 60-min music session through noise-cancelling headphones or a control group (n = 55) receiving standard care. Serum cortisol was measured immediately before and after the intervention by blinded laboratory personnel. Linear mixed-effect models were used, adjusting for covariates including days of IMV and baseline characteristics.
Results
In the intervention group, serum cortisol decreased after the session (mean difference: -1.57 μg/dL; 95% confidence interval [CI]: -2.42 to -0.72), whereas cortisol levels remained stable in the control group (mean difference: -0.14 μg/dL; 95% CI: -0.99 to 0.71). The mixed-effect model demonstrated significant effects of group (F(1,108) = 6.46; p = 0.012), time (F(1,108) = 5.55; p = 0.020), and the group × time interaction (F(1,108) = 7.95; p = 0.006). After adjustment, the intervention remained independently associated with lower postintervention cortisol levels (β = -1.67; 95% CI: -2.90 to -0.44). Each additional IMV day was associated with higher cortisol levels (β = 0.65; 95% CI: 0.24 to 1.06). No significant changes were observed in physiological parameters, indicating haemodynamic and neurological stability.
Conclusions
A standardised music intervention significantly reduced serum cortisol levels in sedated, mechanically ventilated ICU patients without affecting physiological stability. These findings support music as a safe, nonpharmacological adjunct to modulate stress responses in critical care.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.